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Table 5 Interaction effect of the glucocorticoid receptor gene, number of traumatic events, stressful life events, and social support for risk of PTSD when adjusted for age

From: The relationship between glucocorticoid receptor polymorphisms, stressful life events, social support, and post-traumatic stress disorder

Variables Total With childhood trauma Without childhood trauma
n PTSD % OR (95% CI) n PTSD % OR (95% CI) n PTSD % OR (95% CI)
A-C-ML-LT-MS 778 14.7 1.00 161 20.5 1.00 617 13.1 1.00
G-G-HL-HT-LS 418 35.9 3.26(2.46,4.32)a 130 46.2 3.33(1.99,5.57)a 288 33.7 3.26(2.32,4.57)a
A-C-HL-HT-LS 948 33.5 2.94(2.31,3.73)a 227 38.2 2.40(1.49,3.85)a 721 30.4 2.89(2.18,3.83)a
A-G-HL-LT-MS 474 29.5 2.44(1.84,3.25)a 52 36.5 2.23(1.13.4.42)a 422 30.3 2.88(2.11,3.94)a
G-G-ML-LT-LS 330 30.9 2.61(1.92,3.55)a 29 41.4 2.74(1.19,6.29)a 301 29.2 2.73(1.94,3.85)a
All Othersa 288 33.3 2.91(2.12,3.99)a 57 44.6 3.13(1.63,5.98)a 231 30.6 2.92(2.03,4.20)a
  1. ML moderate level stressful life events, HL high level stressful life events, HT high number of traumatic events (more than five traumatic events), LT low number of traumatic events (five or fewer events), MS moderate social support or high social support, LS low social support.
  2. aP<0.05.