Table 3 Clozapine co-prescribing with antipsychotics and mood stabilisers (ranked in descending order of percentage median improvement change on MSE symptom severity scores)
From: Skating on thin ice: pragmatic prescribing for medication refractory schizophrenia
Augmentation | Patients | Median clozapine dose (mg) | Clozapine interquartile range (mg) | Median co-prescribed dose (mg) | Co-prescribed dose interquartile range (mg) | Median improvement % | Improvement IQR % |
|---|---|---|---|---|---|---|---|
Sodium valproate | 22 | 550.0 | 225.0 | 1500 | 800.0 | 62.5 | 21.1 |
Lithium | 16 | 375.0 | 375.0 | 800 | 100.0 | 56.9 | 36.8 |
Amisulpride | 26 | 500.0 | 237.5 | 300 | 200.0 | 53.0 | 39.5 |
Quetiapine | 13 | 550.0 | 159.4 | 400 | 212.5 | 51.0 | 30.5 |
Lamotrigine | 14 | 337.5 | 262.5 | 200 | 37.5 | 43.7 | 32.0 |