Stop or go? Preventive cognitive therapy with guided tapering of antidepressants during pregnancy: study protocol of a pragmatic multicentre non-inferiority randomized controlled trial

Table 1 Assessment per measurement moment

	Method	T0	T1	T2	T3	T4	T5	T6	T7
Clinical Diagnostic Interview (SCID-I)	Int	X		…	…	…	…	X
Depressive symptoms (HDRS)	Int	X		…	X	…	…	X
Peripartum depression (EPDS)	SR		X	X	X		X	X
Anxiety (STAI)	SR		X	X	X		X	X
Affect (I-PANAS-SF)	SR		X	X	X		X	X
Attitudes (DAS)	SR		X	X	X
Daily hassles	Int	X		X	X		X	X
Life events	Int	X		X	X		X	X
Sociodemographic & -economic factors (Mind2Care)	SR		X
Substance use (Mind2Care)	SR		X	X	X		X	X
Medication use	Int	X		X	X		X	X
Medication adherence	SR		X
Medication beliefs	SR		X
Childhood trauma (CTQ)	SR			X
Quality of Life (EQ-5D-5L)	SR		X	X	X		X	X
Health care consumption (TIC-P)	SR		X		X		X	X
Pregnancy related outcomes	CG					X
Neural development (GM)	ME							X
Child behaviour (CBCL)	SR								X
Cortisol (hair strands)	BM		X			X		X
Buccal swab	BM		X					X
Blood sample	BM							X
Meconium (SSRI concentration)	BM					X
Breast milk (SSRI concentration)	BM					X

Int interview, SR self report, CG caregiver, BM biological materials, T0 pre-assesment, T1 baseline, T2 24 weeks of gestation, T3 36 weeks of gestation, T4 delivery, T5 4 weeks postpartum, T6 12 weeks postpartum, T7 18 months postpartum

ISSN: 1471-244X