Normal gray matter volumes in women recovered from anorexia nervosa: a voxel-based morphometry study

BMC Psychiatry

Table 1 Participant characteristics and global tissue volumes in women recovered from anorexia nervosa versus healthy controls

	RAN (n = 22)	HC (n = 22)	Two-sample t-test
Characteristic	Mean ± SD	Mean ± SD	t (df)	P	d
Age	27.32 ± 5.14	26.14 ± 4.64	0.80 (42)	.43	0.24
BMI (kg/m²)^a	20.39 ± 1.66	21.85 ± 1.76	−2.70 (38)	.01	−0.85
BDI	6.36 ± 7.94	1.77 ± 2.69	2.57 (42)	.02	0.77
EDE-Q global score	0.84 ± 0.74	0.19 ± 0.17	4.04 (42)	<.001	1.21
STAI state score	32.14 ± 8.16	25.86 ± 5.21	3.04 (42)	.004	0.92
STAI state score	38.77 ± 11.48	28.36 ± 6.43	3.71 (42)	.001	1.12
GM volume (ml)	635.96 ± 52.03	664.39 ± 44.81	1.94 (42)	.06	−0.59
WM volume (ml)	474.31 ± 51.71	479.70 ± 39.19	0.39 (42)	.70	−0.12
CSF volume (ml)	224.82 ± 30.61	232.19 ± 21.40	0.93 (42)	.36	−0.28
TIV (ml)	1335.09 ± 115.62	1376.28 ± 87.11	1.34 (42)	.19	−0.40
GM fraction (GM divided by TIV)	0.477 ± 0.021	0.483 ± 0.015	1.06 (42)	.30	−0.33
WM fraction (WM divided by TIV)	0.355 ± 0.017	0.348 ± 0.014	−1.39 (42)	.17	0.45
CSF fraction (CSF divided by TIV)	0.168 ± 0.015	0.169 ± 0.012	0.17 (42)	.87	−0.07
Lowest lifetime weight^b	71.84 ± 9.18 (range: 46–85)
Lowest lifetime BMI (kg/m²)^c	14.76 ± 1.83 (range: 10–17)
Age of AN onset	17.36 ± 4.17 (range: 11–32)
Duration of illness (months)^d	32.86 ± 27.47 (range: 6–120)
Duration of recovery (months)^d	51.62 ± 42.70 (range: 12–192)

BDI Beck depression inventory, BMI Body mass index, CSF Cerebrospinal fluid, d Cohen’s d effect size, EDE-Q Eating disorder examination-questionnaire, GM Gray matter, HC Healthy controls, ml milliliters, RAN Recovered anorexia nervosa, STAI State-trait anxiety inventory, TIV Total intracranial volume, WM White matter
^aData not available for three recovered anorexia nervosa women and one healthy control
^bExpressed as percentage of ideal weight, taking into account height, age and gender
^cNot adjusted for age
^dData not available for one recovered anorexia nervosa woman

ISSN: 1471-244X