Group cognitive behavioral therapy modulates the resting-state functional connectivity of amygdala-related network in patients with generalized social anxiety disorder

Table 2 Altered amygdala connectivity with other brain regions

Contrast	Brain region	Brodmann area	MNI Coordinate			T score	Voxels
	Brain region	Brodmann area	x	y	z
Altered amygdala connectivity in GSAD patients before and after treatment
GSAD Pre > GSAD Post
Amygdala L	Putamen R	_	27	12	−9	3.67^a	392
	dmPFC L	46	−27	30	27	4.10^a	329
	dACC R	32	6	39	12	2.88^a	19
Amygdala R	none
Abnormal amygdala connectivity in pre-treatment group compared with HC GSAD Pre > HC
Amygdala L	dmPFC L	46	−30	36	9	2.62^b	11
Amygdala L	dACC R	32	6	39	9	2.76^b	7
Abnormal amygdala connectivity in post-treatment group compared with HC
none

No significant voxels for GSAD Pre < GSAD Post or GSAD Pre < HC
p <0.05, voxel z value >2.3, Gaussian Random Field (GRF) corrected (two-tailed); MNI Montreal Neurologic Institute, GSAD generalized social anxiety disorder (entire cohort, N = 15), HC healthy control (N = 19), Pre pretreatment, Post post-treatment, dmPFC dorsal medial prefrontal cortex, dACC dorsal medial anterior cingulate cortex, L left, R right, vs versus; a: paired sample T-test; b: two sample T-test

ISSN: 1471-244X