Depression treatment decreases healthcare expenditures among working age patients with comorbid conditions and type 2 diabetes mellitus along with newly-diagnosed depression

Table 3 IPTW adjusted association between depression treatment and healthcare expenditures stratified by coexisting condition type. Among medicaid beneficiaries with type 2 diabetes mellitus and newly diagnosed depression. Multi-state medicaid claims database – 2000–2008

	ALL expenditures				T2DM-related expenditures
Depression treatment categories	Change	95 % CI		Sig	Change	95 % CI		Sig
Dominant
Only antidepressants	−0.23	−0.41	0.01		−0.23	−0.44	0.06
Only psychotherapy	−0.48	−0.59	−0.34	***	−0.41	−0.55	−0.23	***
Antidepressants and Psychotherapy	−0.41	−0.57	−0.19	**	−0.24	−0.48	0.1
Concordant ONLY
Only antidepressants	−0.21	−0.33	−0.08	**	−0.05	−0.22	0.16
Only psychotherapy	−0.11	−0.26	0.06		−0.19	−0.36	0.03
Antidepressants and Psychotherapy	−0.23	−0.38	−0.04	*	−0.27	−0.44	−0.06	*
Discordant only
Only antidepressants	−0.18	−0.31	−0.02	*	−0.09	−0.26	0.13
Only psychotherapy	−0.09	−0.29	0.18		−0.1	−0.33	0.2
Antidepressants and Psychotherapy	−0.29	−0.45	−0.08	*	−0.1	−0.35	0.23
Both concordant & discordant
Only antidepressants	−0.1	−0.2	0.01		−0.1	−0.23	0.06
Only psychotherapy	−0.21	−0.31	−0.09	***	−0.34	−0.45	−0.19	***
Antidepressants and Psychotherapy	−0.27	−0.38	−0.15	***	−0.1	−0.28	0.14

Reference Group: No Depression Treatment
Note: Study sample was comprised of adults with type 2 diabetes mellitus aged 18–64 years with at least one coexisting dominant, concordant, or discordant chronic physical condition and who were alive, not dually eligible for Medicare, and continuously enrolled in fee-for-service Medicaid for at least 24 months (N = 5295); includes Medicaid data from three states: Illinois, Texas, New York
All healthcare expenditures included inpatient, outpatient and prescription drug-related expenditures; T2DM-related expenditures included inpatient and outpatient expenditures due to T2DM-related diagnosis. The expenditures were log transformed
Asterisks indicate statistical significance and are based on mixed effects models; ***P < .001; **.001 ≤ P < .01; *.01 ≤ P < .05
T2DM Type 2 Diabetes Mellitus; depression: Major Depressive Disorder; IPTW Inverse Probability Treatment Weights, SE Standard Error

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