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Fig. 1 | BMC Psychiatry

Fig. 1

From: DNA hypomethylation of Synapsin II CpG islands associates with increased gene expression in bipolar disorder and major depression

Fig. 1

DNA methylation is decreased in individuals with mood disorders at the SYN2 CpG island. a Graphical representations of the CpG islands predicted at the promoter and first exons of Synapsin genes. b Percent methylation levels for individual CpGs at SYN2 show some significant (p < 0.05) or suggestive (p < 0.1) decreased levels of DNA methylation in BD and more in MDD, while several CpGs have no differences at all. The CpG-to-CpG correlation matrix shows some clusters of correlated percent methylation levels with others seemingly completely independent. The cluster at chr3:12046417-12046478, where 3 consecutive CpGs have decreased DNA methylation levels, overlaps with a predicted binding site for EZH2

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BMC Psychiatry

ISSN: 1471-244X

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