Serotonin-1A receptor alterations in depression: a meta-analysis of molecular imaging studies

BMC Psychiatry

Table 1 Key characteristics of selected studies

1st author	Publication year	Method/Ligand	Reference region	Diagnosis	Severity ranting tools	Severity score	Controls (F) + age	Patients (F) + age	Treatment
Wayne C. Drevets	1999	PET [11C]WAY-100635	Cerebellum	MDD, BPII	HAM-17	22 ± 6.4	8 (4) 35.3 ± 13.5	12 (7) 35.8 ± 9.7	Drug free ≥2 week
Sargent P. A^a.	2000	PET [11C]WAY-100635	Cerebellum	MDD, BPII	HAM-17	14.1 ± 194.9	18 (1) 36.4 ± 8.3	35 (3) 40 ± 34.5	Drug free ≥12
Z Bhagwagar	2004	PET [11C]WAY-100635	Cerebellum	MDD	HAM-7	2.3 ± 1	18 (0) 43.2 ± 13	14 (0) 48 ± 14.9	Drug free ≥25.7 week
Carolyn Cidis Meltzer	2004	PET [11C]WAY-100635	Plasma	MDD	HAM-17	18.1 ± 2.7	17 (9) 70 ± 6.7	17 (13) 71.4 ± 5.9	Drug free ≥2 week
Jussi Hirvonen△	2008	PET [11C]WAY-100635	Plasma	MDD	HAM-17	18.1 ± 2.9	15 (8) 32.6 ± 7.7	21 (8) 40.1 ± 9	Drug free ≥17.1 week
Eydie L. Moses-kolko	2008	PET [11C]WAY-100635	Cerebellum	Postpartum D.	HAM-17	21 ± 4.3	7 (7) 33 ± 3.9	9 (9) 26.9 ± 7.9	7 patients rdrug naïve
Ramin V. Parsey ^a△	2006b	PET [11C]WAY-100635	Cerebellum	MDD	HAM-17	25.7 ± 7.08	43 (24) 38.2 ± 15	28 (7) 38.5 ± 29.3	Drug free ≥2 week
Gregory M. Sullivan△	2009	PET [11C]WAY-100635	Cerebellar white matter	BPII	HAM-17	18 ± 4.9	47 (27) 38.1 ± 14.7	32 (19) 38.4 ± 9.7	Drug free ≥2 week
Jeffrey Miller^a△	2012	PET [11C]WAY-100635	Cerebellum white matter	MDD	HAM-17	24.6 ± 5.3	51 (29) 37.3 ± 14.4	24 (17) 35 ± 13.3	Drug free ≥3
Allison C. Nugent	2013a	PET [11C]WAY-100635	Cerebellar white matte	BPII	MADRS	23 ± 10	33 ± 9.4	26 (19) 33 ± 9.5	Drug free ≥3 week

MDD major depressive disorder, BP bipolar depression, PET positron emission tomography, HAMD Hamilton depression scale, MADRS Montgomery and Asberg depression rating scale
^aData from subgroups were combined and averaged (severity score, age, BP values)
ΔBP values were acquired from figures by graphical software (GetData Graph Digitizer v2.2)

ISSN: 1471-244X