Table 1 Schedule of enrolment, intervention and assessments based on SPIRIT 2013 guidelines [27]

Informed Consent

●

Eligibility

●

Demographic data

●

Height

●

Medical & Psychiatric History

●

Self-reported drug use

●

Concomitant medications

●

Intervention

Treatment as usual (counselling) offered weekly

Dose of Lisdexamfetamine (mg)-dispensed daily

100

150

200

250

250

200

150

100

End

FU

Baseline Measures

MOCA, AUDIT, WTAR, Wender Utah Scale

●

Primary Outcomes

 Brief Psychiatric Scale: psychosis & hostility items

●

●

●

●

●

●

●

●

●

●

 Vital Signs^a (Blood pressure, pulse, temperature)

●

●

●^t

●^t

●^t

●^t

●

●

●

●

●

 Insomnia Severity Index

●

●

●

●

●

●

 Patient Health Questionnaire 15

●

●

●

●

 Patient Health Questionnaire 9

●

●

●

●

●

●

 Generalized Anxiety Disorder 7

●

●

●

●

●

●

 Weight (in kilograms)

●

●

●

●

●

 Adverse Events Log

●

●

●

●

●

●

●

●

●

●

 Electrocardiogram

●

●

●

 TSQM-side-effects item

●

●

●

●

●

●

●

●

●

 Proportion completing dose escalation phase

●

Secondary Outcomes

 Substance Use TLFB-MA (Days Used)

●

●

●

●

●

●

●

●

●

●

●

 Urine Drug Screen (positive MA)

●^d

●

●

●

●

●

●

●

●

●

●

 Substance Use TLFB-MA (Days Used)

●

●

●

●

●

●

●

●

●

●

 Urine Drug Screen^c

●^d

●

●

●

●

●

●

●

●

●

●

 TSQM-effectiveness item

●

●

●

●

●

●

●

●

●

●

 Visual Analogue Scale for MA craving

●^t

●^t

●^t

●^t

●^t

●

●

●

●

●

 Amphetamine Withdrawal Questionnaire

●^t

●^t

●^t

●^t

●^t

●

●

●

●

●

 Severity of Dependence Scale

●

●

●

 Adapted Opiate Treatment Index (HIV & crime scales)

●

●

●

 TSQM-convenience & global satisfaction items

●

●

●

●

●

●

●

●

●

●

 Proportion discontinuing once enrolled

●

●

●

●

●

●

●

●

 Price would Pay

●^b

●^b

●^b

●^b

●^b

 Similarity to MA Visual Analogue Scale

●^b

●^b

●^b

●^b

●^b

 Drug Effects Questionnaire 5

●^b

●^b

●^b

●^b

●^b

 Acute Subjective Response to Substances

●^b

●^b

●^b

●^b

●^b

 Trail-making Test

●^t

●^t

●^t

●^t

●^t

●

 Rey Auditory Verbal Learning Task

●^t

●^t

●^t

●^t

●^t

●

 Digit-span sequencing

●^t

●^t

●^t

●^t

●^t

●

 Flankers Test with no-go

●

●

●

●

 Digit Symbol Substitution

●

●

●

●

 Rapid Information Processing

●

●

●

●