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Table 5 Association between individual risk factors for QT-related arrhythmias and Torsades de Pointes (TdP), and TdP risk category of antipsychotics

From: Clinicians’ adherence to clinical practice guidelines for cardiac function monitoring during antipsychotic treatment: a retrospective report on 434 patients with severe mental illness

  AP Torsades de Point risk category, n (%)   
Factor A B C χ 2 P-value
Presence of comorbid somatic illnesses 82 (50.6) 556 (48.6) 29 (69.0) 6.9 0.03
Presence of cardiac comorbidities 2 (1.2) 45 (3.9) 4 (9.5) 6.8a 0.03
Presence of vascular comorbidities 10 (6.2) 123 (10.8) 11 (26.2) 14.0 0.01
Use of pharmacological treatments determining QT prolongation during AP therapy 134 (82.7) 885 (77.4) 41 (97.6) 11.6 0.003
  1. Category A: drugs with known risk of inducing TdP
  2. Category B: drugs with possible risk of inducing TdP
  3. Category C: drugs with conditional risk of TdP
  4. AP antipsychotic
  5. a χ 21000 sample bootstrap