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Table 3 Association between use of acetaminophen by mother during pregnancy and mental health outcomes at the age of 6 years among boys (N = 1812) and girls (N = 1658)

From: Is intrauterine exposure to acetaminophen associated with emotional and hyperactivity problems during childhood? Findings from the 2004 Pelotas birth cohort

Outcomes Frequency of outcome according to use of acetaminophen during pregnancy N (%) Crude analysis Adjusted analysisa
Exposed
n (%)
Not exposed
n (%)
OR
(95% CI)
OR
(95% CI)
p b
Boys
 Total SDQ (score ≥ 17 pts) 63 (12.00) 149 (11.58) 1.04 (0.76–1.43) 1.28 (0.90–1.83) 0.163
 Emotional symptoms (score ≥ 5 pts) 83 (15.81) 154 (11.97) 1.38 (1.04–1.84) 1.47 (1.07–2.02) 0.018
 Conduct problems (score ≥ 4 pts) 72 (13.71) 223 (17.33) 0.76 (0.57–1.02) 0.93 (0.68–1.27) 0.641
 Hyperactivity/inattention (score ≥ 7 pts) 93 (17.71) 195 (15.15) 1.21 (0.92–1.58) 1.42 (1.06–1.92) 0.020
 Peer relationship problems (score ≥ 4 pts) 81 (15.43) 196 (15.23) 1.02 (0.77–1.35) 1.25 (0.91–1.71) 0.167
 Prosocial behavior (score ≤ 4 pts) 5 (0.95) 18 (1.40) 0.68 (0.25–1.84) 0.60 (0.19–1.88) 0.376
Girls
 Total SDQ (score ≥ 17 pts) 39 (8.86) 122 (10.02) 0.87 (0.60–1.28) 1.02 (0.67–1.54) 0.943
 Emotional symptoms (score ≥ 5 pts) 54 (12.27) 181 (14.86) 0.80 (0.58–1.11) 0.90 (0.63–1.28) 0.557
 Conduct problems (score ≥ 4 pts) 47 (10.68) 173 (14.20) 0.72 (0.51–1.02) 0.79 (0.54–1.16) 0.226
 Hyperactivity/inattention (score ≥ 7 pts) 44 (10.00) 149 (12.23) 0.80 (0.56–1.14) 0.76 (0.51–1.12) 0.165
 Peer relationship problems (score ≥ 4 pts) 43 (9.77) 170 (13.96) 0.67 (0.47–0.95) 0.88 (0.59–1.31) 0.535
 Prosocial behavior (score ≤ 4 pts) 3 (0.68) 15 (1.23) 0.55 (0.16–1.91) 0.73 (0.20–2.69) 0.630
  1. aLogistic regression adjusted according to maternal age, parity, national economic index, maternal educational level, smoking during pregnancy, alcohol during pregnancy, maternal skin color, infection during pregnancy, pre-gestational BMI, presence of maternal mood disorder and use of other analgesics during pregnancy. N after adjustment: 1619 for boys; 1484 for girls. bp-values marked in bold denote statistically significant results