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Table 5 Sensitivity analysis considering Edinburgh Postnatal Depression Scale at 12 months follow-up interview for the association between exposure to acetaminophen during pregnancy and SDQ total and subscales problems of children at 6 and 11 years of age

From: Is intrauterine exposure to acetaminophen associated with emotional and hyperactivity problems during childhood? Findings from the 2004 Pelotas birth cohort

Outcomes 6 years 11 years
Adjusted analysisa Adjusted analysisa
OR (95% CI) P b OR (95% CI) P b
Boys
 Total SDQ (score ≥ 17 pts) 1.22 (0.85–1.75) 0.291 1.22 (0.89–1.66) 0.221
 Emotional symptoms  (score ≥ 5 pts) 1.42 (1.02–1.97) 0.038 1.33 (1.01–1.76) 0.045
 Conduct problems (score ≥ 4 pts) 0.89 (0.64–1.24) 0.503 1.09 (0.78–1.54) 0.609
 Hyperactivity/inattention (score ≥ 7 pts) 1.43 (1.05–1.94) 0.022 1.25 (0.94–1.65) 0.121
 Peer relationship problems (score ≥ 4 pts) 1.21 (0.88–1.67) 0.251 1.14 (0.83–1.57) 0.415
 Prosocial behavior (score ≤ 4 pts) 0.65 (0.21–2.03) 0.457 0.48 (0.14–1.66) 0.246
Girls
 Total SDQ (score ≥ 17 pts) 0.99 (0.65–1.51) 0.954 1.14 (0.78–1.67) 0.503
 Emotional symptoms  (score ≥ 5 pts) 0.90 (0.63–1.28) 0.554 1.06 (0.79–1.42) 0.694
 Conduct problems (score ≥ 4 pts) 0.81 (0.55–1.19) 0.290 0.73 (0.49–1.10) 0.135
 Hyperactivity/inattention (score ≥ 7 pts) 0.76 (0.51–1.13) 0.175 1.10 (0.76–1.61) 0.613
 Peer relationship problems (score ≥ 4 pts) 0.89 (0.60–1.32) 0.559 1.31 (0.90–1.91) 0.155
 Prosocial behavior (scor e ≤ 4 pts) 0.75 (0.20–2.80) 0.663 1.39 (0.47–4.15) 0.553
  1. aLogistic regression adjusted according to maternal age, parity, national economic index, maternal educational level, smoking during pregnancy, alcohol consumption during pregnancy, maternal skin color, infection during pregnancy, pre-gestational BMI, presence of maternal depression and use of other analgesics during pregnancy. N after adjustment: 1.555 for boys and 1.137 for girls at 6 years; 1.523 for boys and 1.442 for girls at 11 years. bp-values marked in bold denote statistically significant results