Is intrauterine exposure to acetaminophen associated with emotional and hyperactivity problems during childhood? Findings from the 2004 Pelotas birth cohort

Table 5 Sensitivity analysis considering Edinburgh Postnatal Depression Scale at 12 months follow-up interview for the association between exposure to acetaminophen during pregnancy and SDQ total and subscales problems of children at 6 and 11 years of age

Outcomes	6 years		11 years
	Adjusted analysis^a		Adjusted analysis^a
	OR (95% CI)	P ^b	OR (95% CI)	P ^b
Boys
Total SDQ (score ≥ 17 pts)	1.22 (0.85–1.75)	0.291	1.22 (0.89–1.66)	0.221
Emotional symptoms (score ≥ 5 pts)	1.42 (1.02–1.97)	0.038	1.33 (1.01–1.76)	0.045
Conduct problems (score ≥ 4 pts)	0.89 (0.64–1.24)	0.503	1.09 (0.78–1.54)	0.609
Hyperactivity/inattention (score ≥ 7 pts)	1.43 (1.05–1.94)	0.022	1.25 (0.94–1.65)	0.121
Peer relationship problems (score ≥ 4 pts)	1.21 (0.88–1.67)	0.251	1.14 (0.83–1.57)	0.415
Prosocial behavior (score ≤ 4 pts)	0.65 (0.21–2.03)	0.457	0.48 (0.14–1.66)	0.246
Girls
Total SDQ (score ≥ 17 pts)	0.99 (0.65–1.51)	0.954	1.14 (0.78–1.67)	0.503
Emotional symptoms (score ≥ 5 pts)	0.90 (0.63–1.28)	0.554	1.06 (0.79–1.42)	0.694
Conduct problems (score ≥ 4 pts)	0.81 (0.55–1.19)	0.290	0.73 (0.49–1.10)	0.135
Hyperactivity/inattention (score ≥ 7 pts)	0.76 (0.51–1.13)	0.175	1.10 (0.76–1.61)	0.613
Peer relationship problems (score ≥ 4 pts)	0.89 (0.60–1.32)	0.559	1.31 (0.90–1.91)	0.155
Prosocial behavior (scor e ≤ 4 pts)	0.75 (0.20–2.80)	0.663	1.39 (0.47–4.15)	0.553

^aLogistic regression adjusted according to maternal age, parity, national economic index, maternal educational level, smoking during pregnancy, alcohol consumption during pregnancy, maternal skin color, infection during pregnancy, pre-gestational BMI, presence of maternal depression and use of other analgesics during pregnancy. N after adjustment: 1.555 for boys and 1.137 for girls at 6 years; 1.523 for boys and 1.442 for girls at 11 years. ^bp-values marked in bold denote statistically significant results

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