Table 5 The probability of first generation antipsychotics induced adverse drug reactions in patients with schizophrenia at Amanuel Specialized Mental Hospital
Category of ADR; n(%) | Type of ADR (Frequency) | FDAs associated with the ADR |
|---|---|---|
Definite reaction 67 (22.3%) | Dizziness (28) | Chlorpromazine |
Irregularity in heart beat (11) | Chlorpromazine | |
Sedation (14) | Chlorpromazine | |
EPS (14) | Fluphenazine depot (11) + Haloperidol (8) | |
Probable reaction 145 (48.3) | EPS (44) | Haloperidol(23) + fluphenazine depot(21) |
Sedation (15) | Chlorpromazine(11) + thioridazine(4) | |
Constipation (9) | Fluphenazine depot | |
Dizziness (46) | Chlorpromazine(23) + Haloperidol(23) | |
Sexual dysfunction (3) | Chlorpromazine(2) + Haloperidol(1) | |
Irregularity in heart beat (37) | Chlorpromazine(20) + fluphenazine depot(17) | |
Possible reaction 75 (25.0) | Irregularity in heart beat (31) | Chlorpromazine (23) + Haloperidol (8) |
Dizziness (12) | Chlorpromazine | |
Dry mouth (10) | Chlorpromazine | |
Insomnia (9) | Haloperidol | |
Menstrual abnormality (5) | Fluphenazine depot | |
Drooling (11) | Fluphenazine depot |