Gender-disease interaction on brain cerebral metabolism in cancer patients with depressive symptoms

BMC Psychiatry

Table 2 Results of the gender and cancer factors two-way ANOVA of the 18F-FDG PET brain image

Two-way ANOVA	Cluster size	Anatomical region	Hemisphere	BA	F-value	Peak coordinates(x,y,z)(mm)
Cancer main effect	2030	Frontal_sup	Left	6	13.2	−21 -12 63
	1551	Parietal_sup	Right	40	11.59	33 –63 52
	1066	Supp_motor_area	Left	6	12.46	−7 8 74
	374	Frontal_mid_orb	Left	–	10.55	−33 47 –8
	317	Frontal_mid	Right	40	11.59	33 –63 52
	143	Cingulum_mid	Left	5	8.95	−7 -39 51
	141	Parietal_inf	Left	40	8.7	38 –57 54
	138	Frontal_sup_medical	Left	8	9.33	−7 46 50
Gender main effect	21,928	Cerebellum posterior lobe	Right	–	23.41	22 –68 -30
	20,683	Cerebellum posterior lobe	Left	–	19.01	−17 -67 -32
	1195	Temporal_inf	Left	20	11.63	−44 -51 -14
	1100	Cuneus	Right	7	11.91	11 –76 42
	495	Cingulum_mid	Left	24	10.37	−10 -6 39
	378	Precentral	Left	6	10.54	−21 -11 62
	127	Frontal_sup	Right	6	9.53	20 –14 70
Interaction	356	Frontal_sup	Left	6	16.44	−20 -12 61
	305	Precuneus	Left	7	14.67	−4 -76 43
	233	Postcentral	Right	4	16.33	28 –29 59
	209	Frontal_sup	Right	6	17.40	19 –14 70

For each significant cluster, we reported the F-value (peak intensity) and MNI coordinates at the position of the maximum, the cluster size (k) and the corresponding Brodmann area (BA). Only clusters with k > 100 are shown

ISSN: 1471-244X