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Table 1 Clinical and sociodemographic characteristics of patients

From: Predictors of the effectiveness of an early medication change strategy in patients with major depressive disorder

Characteristic

EMC (n = 97)

TAU (n = 95)

p-value

Patient characteristics

 Age (mean +/− SD)

39.4 ± 11.5

38.9 ± 12.2

0.796

 Female sex – n (%)

55 (57)

52 (55)

0.784

Symptom-based subtypes - n (%)

 Melancholic MDD

78 (80)

81 (85)

0.721

 Atypical MDD

36 (37)

35 (37)

0.881

 Anxious MDD

65 (67)

67 (71)

0.762

 MDD with suicidality

80 (84)

75 (79)

0.389

 1st episode - n (%)

30 (31)

31 (33)

0.924

Severity of depression (IDS-C30)

 Mean IDS-C30 score (mean +/− SD)

44.2 ± 8.7

45.3 ± 8.4

0.352

 Mean IDS-SR30 score (mean +/− SD)

45.5 ± 10.3

45.5 ± 10.1

0.958

 Axis I - n (%)

52 (54)

52 (55)

0.996

 Axis II - n (%)

42 (43)

37 (39)

0.554

Physical comorbidities CIRS

 Total severity score ((mean +/− SD)

1.9 ± 2.1

1.7 ± 1.9

0.506

 Cardiac

0.1 ± 0.4

0.1 ± 0.1

0.460

 Hypertension

0.02 ± 0.1

0.02 ± 0.1

0.983

 Vascular

0.2 ± 0.5

0.3 ± 0.6

0.136

 Respiratory

0.4 ± 0.7

0.3 ± 0.6

0.339

 ENT

0.1 ± 0.3

0.1 ± 0.5

0.402

 Upper GI

0.1 ± 0.4

0.1 ± 0.1

0.470

 Lower GI

0.1 ± 0.3

0.2 ± 0.5

0.195

 Hepatic

0.01 ± 0.1

0.02 ± 0.2

0.645

 Renal

0.1 ± 0.3

0.1 ± 0.4

0.543

 Musculo-sceletal-integumentary

0.4 ± 0.9

0.3 ± 0.6

0.275

 Neurological

2.1 ± 1.2

2.4 ± 1.4

0.334

 Endocrine-metabolic

0.2 ± 0.5

0.2 ± 0.5

0.208

 Psychiatric somatic symptoms (HAMD-17 item 11)

1.6 ± 1.0

1.8 ± 1.0

0.104

  1. SD Standard deviation, EMC Early Medication Change, TAU Treatment as Usual, MDD Major Depressive Disorder, IDS-30 30-item Quick Inventory of Depressive Symptomatology, C Clinician–Rated, SR Self-Rating, CIRS Clinical incident rating scale, without the psychiatric somatic symptoms; Data concerning age, gender, 1st episode/recurrent MDD, severity of depression, psychiatric and physical comorbidities were published before in [18].