Cannabidiol enhancement of exposure therapy in treatment refractory patients with phobias: study protocol of a randomized controlled trial

Table 1 Overview of assessments

Measure	Assessment	T0	T1	T2	T3	T4	T5	T6	Treat-ments
SCID	Diagnosis	x
General patient characteristics	Demographic information	x
Clinical background	Therapy history	x
CTQ	Childhood trauma	x
AQ	Autism quotient	x
FQ	Presence and severity phobic symptoms	x		x		x	x	x	x
BAI	Anxiety severity	x		x		x	x	x	x
CGI	Clinical global impression								x
SUDS	Degree of habituation and extinction								x
BDI	Depression	x		x		x	x	x
BSQ	Somatic symptoms	x		x		x	x	x
EQ5D	Quality of life	x		x		x	x	x
Tic-P	Loss of work and productivity plus health care costs	x		x		x	x	x
SPAI	Social phobia and anxiety severity	x		x		x	x	x
LSAS	Social anxiety severity (SOC PHOB)	x		x		x	x	x
PDSS	Panic disorder severity (PD + AGO)	x		x		x	x	x
MI	Mobility inventory (PD + AGO)	x		x		x	x	x
ACQ	Agoraphobia severity (PD + AGO)	x		x		x	x	x
Fear conditioning task	Acquisition and extinction of fear learning	x	x		x
Blood	CBD level, DNA, epigenetics		x		x

Questionnaires that are only assessed for a specific diagnosis are specified between brackets (panic disorder with agoraphobia = PD + AGO, social phobia = SOC PHOB). T0 = Baseline, T1 = First medication administration, T2 = Mid treatment, T3 = Last medication administration, T4 = Post treatment, T5 = Follow up (3 months), T6 = Follow up (6 months), Treatments = All 8 therapy sessions. SCID Structured Clinical Interview for DSM disorders axis I, CTQ Childhood Trauma Questionnaire, AQ Autism spectrum Quotient, FQ Fear Questionnaire, BAI Beck Anxiety Inventory, CGI Clinical Global Impression, SUDS Subjective Units of Distress Scale, BDI Beck Depression Inventory, BSQ Bodily Sensations Questionnaire, EQ5D EuroQol, Tic-P Trimbos and iMTA questionnaire on Costs associated with Psychiatric illness, SPAI Social Phobia and Anxiety Inventory, LSAS Liebowitz Social Anxiety Scale, PDSS Panic Disorder Severity Scale, MI Mobility Inventory, ACQ Agoraphobic Cognitions Questionnaire

ISSN: 1471-244X