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Table 1 Characteristics of patients stratified by depression severity

From: Associations of mood symptoms with NYHA functional classes in angina pectoris patients: a cross-sectional study

Variables Total Non-depressed depressed p value p value
mild dep. mod-severe dep.
N = 443 N = 271 N = 123 N = 49 not clinical vs clinical nondepressed vs depressed
  61.2% (score < 5) 27.8% 11.1% (score ≥ 10)
Demographics
 Age,mean ± SD,y 63.9 ± 9.8 63.0 ± 9.5 65.5 ± 10.0 64.9 ± 10.8 0.47 .019
 Male,No.(%) 337(76.1) 223(82.3) 79(64.2) 35(71.4) 0.42 <.001
 Body mass index,mean ± SD,kg/m2 24.5 ± 3.1 24.6 ± 2.7 24.4 ± 3.5 24.2 ± 3.7 0.51 0.41
Clinical characteristics
 NYHA class I-IV,No.(%) .017 <.001
  Class I 115(26.0) 79(29.2) 27(22.0) 9(18.4)   
  Class II 261(58.9) 169(62.4) 66(53.7) 26(53.1)   
  Class III-IV 67(15.1) 23(8.5) 30(24.4) 14(28.6)   
 Ejection Fraction,mean ± SD,% 59.3 ± 11.0 60.3 ± 9.9 N = 238 56.4 ± 12.3 N = 112 60.8 ± 12.0 N = 43 0.33 .024
 Nt-ProBNP,median(interquartile),pg/mL 123(50–382) 106(48–309) N = 231 180(72–721) N = 99 124(47–341) N = 39 0.98 .013
 Creatinine Clearance,mean ± SD,ml/min 65.5 ± 21.7 68.4 ± 20.1 61.1 ± 22.4 60.7 ± 26.3 0.17 <.001
 Type of angina pectoris,No.(%) 0.92 0.94
  Unstable angina pectoris 256(57.8) 157(57.9) 71(57.7) 28(57.1)   
  Stable angina pectoris 187(42.2) 114(42.1) 52(42.3) 21(42.9)   
 Severity of coronary stenosis,No.(%) 0.62 0.34
  1 93(21.0) 51(18.8) 33(26.8) 9(18.4)   
  2 82(18.5) 54(19.9) 19(15.4) 9(18.4)   
  3 268(60.5) 166(61.3) 71(57.7) 31(63.3)   
Social factors
 Education,No.(%) .041 <.001
  less than 6 years 115(26.0) 50(18.5) 44(35.8) 21(42.9)   
  7–9 years 126(28.4) 85(31.4) 31(25.2) 10(20.4)   
  10–12 years 97(21.9) 63(23.2) 25(20.3) 9(18.4)   
  more than 12 years 105(23.7) 73(26.9) 23(18.7) 9(18.4)   
 Marriage,No.(%) .068 .023
  Married 412(93.0) 258(95.2) 112(91.1) 42(85.7)   
  Divorced or Widowed or Single 31(7.0) 13(4.8) 11(8.9) 7(14.3)   
Medical history,No.(%)
 Hypertension 276(62.3) 162(59.8) 78(63.4) 34(69.4) 0.25 0.26
 Diabetes mellitus 154(34.8) 83(30.6) 52(42.3) 19(38.8) 0.53 .022
 Prior PCI 167(37.7) 102(37.6) 43(35.0) 22(44.9) 0.27 0.97
 History of antidepressant treatment 17(3.8) 4(1.5) 6(4.9) 7(14.3) <.001 .001
Medication use,No.(%)
 ACEI or ARB 317(71.6) 190(70.1) 93(75.6) 34(69.4) 0.72 0.40
 β blocker 384(86.7) 230(84.9) 109(88.6) 45(91.8) 0.26 0.16
 Mono antipletelet therapy 63(14.2) 38(14.0) 19(15.4) 6(12.2) 0.67 0.88
 Dual antiplatelet therapy 370(83.5) 228(84.1) 100(81.3) 42(85.7) 0.66 0.66
 Statin 430(97.1) 266(98.2) 120(97.6) 47(95.9) 0.36 0.46
 Aldosterone receptor antagonist 42(9.5) 16(5.9) 18(14.6) 8(16.3) .083 .001
 Loop diuretic 47(10.6) 18(6.6) 20(16.3) 9(18.4) .062 <.001
 Anticoagulant 20(4.5) 10(3.7) 8(6.5) 2(4.1) > 0.99 0.29
 Antidepressant 9(2.0) 4(1.5) 0(0) 5(10.2) .001 0.49
Somatic symptom score,mean(SD) 3.05(2.87) 1.39(1.18) 4.37(1.44) 8.90(2.81) <.001 <.001
Cognitive symptom score,mean(SD) 1.36(1.98) 0.39(0.63) 1.98(1.46) 5.16(2.73) <.001 <.001
Somatic / Dep. symptom score,% 69.2 78.1 68.9 63.3   
  1. Note: Clinical characteristics were compared between subjects with PHQ-9 score < 10 and ≥ 10 (not clinical vs clinical) as well as < 5 and ≥ 5 (non-depressed vs depressed)
  2. Abbreviation: dep.: depression; mod-severe dep.: moderate or severe depression; PCI: percutaneous transluminal coronary intervention; ACEI: angiotensin converting enzyme inhibitor; ARB: angiotensin receptor blocker