Table 1 Characteristics of patients stratified by depression severity
Variables | Total | Non-depressed | depressed | p value | p value | |
|---|---|---|---|---|---|---|
mild dep. | mod-severe dep. | |||||
N = 443 | N = 271 | N = 123 | N = 49 | not clinical vs clinical | nondepressed vs depressed | |
|  | 61.2% (score < 5) | 27.8% | 11.1% (score ≥ 10) | |||
Demographics | ||||||
 Age,mean ± SD,y | 63.9 ± 9.8 | 63.0 ± 9.5 | 65.5 ± 10.0 | 64.9 ± 10.8 | 0.47 | .019 |
 Male,No.(%) | 337(76.1) | 223(82.3) | 79(64.2) | 35(71.4) | 0.42 | <.001 |
 Body mass index,mean ± SD,kg/m2 | 24.5 ± 3.1 | 24.6 ± 2.7 | 24.4 ± 3.5 | 24.2 ± 3.7 | 0.51 | 0.41 |
Clinical characteristics | ||||||
 NYHA class I-IV,No.(%) | .017 | <.001 | ||||
  Class I | 115(26.0) | 79(29.2) | 27(22.0) | 9(18.4) |  |  |
  Class II | 261(58.9) | 169(62.4) | 66(53.7) | 26(53.1) |  |  |
  Class III-IV | 67(15.1) | 23(8.5) | 30(24.4) | 14(28.6) |  |  |
 Ejection Fraction,mean ± SD,% | 59.3 ± 11.0 | 60.3 ± 9.9 N = 238 | 56.4 ± 12.3 N = 112 | 60.8 ± 12.0 N = 43 | 0.33 | .024 |
 Nt-ProBNP,median(interquartile),pg/mL | 123(50–382) | 106(48–309) N = 231 | 180(72–721) N = 99 | 124(47–341) N = 39 | 0.98 | .013 |
 Creatinine Clearance,mean ± SD,ml/min | 65.5 ± 21.7 | 68.4 ± 20.1 | 61.1 ± 22.4 | 60.7 ± 26.3 | 0.17 | <.001 |
 Type of angina pectoris,No.(%) | 0.92 | 0.94 | ||||
  Unstable angina pectoris | 256(57.8) | 157(57.9) | 71(57.7) | 28(57.1) |  |  |
  Stable angina pectoris | 187(42.2) | 114(42.1) | 52(42.3) | 21(42.9) |  |  |
 Severity of coronary stenosis,No.(%) | 0.62 | 0.34 | ||||
  1 | 93(21.0) | 51(18.8) | 33(26.8) | 9(18.4) |  |  |
  2 | 82(18.5) | 54(19.9) | 19(15.4) | 9(18.4) |  |  |
  3 | 268(60.5) | 166(61.3) | 71(57.7) | 31(63.3) |  |  |
Social factors | ||||||
 Education,No.(%) | .041 | <.001 | ||||
  less than 6 years | 115(26.0) | 50(18.5) | 44(35.8) | 21(42.9) |  |  |
  7–9 years | 126(28.4) | 85(31.4) | 31(25.2) | 10(20.4) |  |  |
  10–12 years | 97(21.9) | 63(23.2) | 25(20.3) | 9(18.4) |  |  |
  more than 12 years | 105(23.7) | 73(26.9) | 23(18.7) | 9(18.4) |  |  |
 Marriage,No.(%) | .068 | .023 | ||||
  Married | 412(93.0) | 258(95.2) | 112(91.1) | 42(85.7) |  |  |
  Divorced or Widowed or Single | 31(7.0) | 13(4.8) | 11(8.9) | 7(14.3) |  |  |
Medical history,No.(%) | ||||||
 Hypertension | 276(62.3) | 162(59.8) | 78(63.4) | 34(69.4) | 0.25 | 0.26 |
 Diabetes mellitus | 154(34.8) | 83(30.6) | 52(42.3) | 19(38.8) | 0.53 | .022 |
 Prior PCI | 167(37.7) | 102(37.6) | 43(35.0) | 22(44.9) | 0.27 | 0.97 |
 History of antidepressant treatment | 17(3.8) | 4(1.5) | 6(4.9) | 7(14.3) | <.001 | .001 |
Medication use,No.(%) | ||||||
 ACEI or ARB | 317(71.6) | 190(70.1) | 93(75.6) | 34(69.4) | 0.72 | 0.40 |
 β blocker | 384(86.7) | 230(84.9) | 109(88.6) | 45(91.8) | 0.26 | 0.16 |
 Mono antipletelet therapy | 63(14.2) | 38(14.0) | 19(15.4) | 6(12.2) | 0.67 | 0.88 |
 Dual antiplatelet therapy | 370(83.5) | 228(84.1) | 100(81.3) | 42(85.7) | 0.66 | 0.66 |
 Statin | 430(97.1) | 266(98.2) | 120(97.6) | 47(95.9) | 0.36 | 0.46 |
 Aldosterone receptor antagonist | 42(9.5) | 16(5.9) | 18(14.6) | 8(16.3) | .083 | .001 |
 Loop diuretic | 47(10.6) | 18(6.6) | 20(16.3) | 9(18.4) | .062 | <.001 |
 Anticoagulant | 20(4.5) | 10(3.7) | 8(6.5) | 2(4.1) | > 0.99 | 0.29 |
 Antidepressant | 9(2.0) | 4(1.5) | 0(0) | 5(10.2) | .001 | 0.49 |
Somatic symptom score,mean(SD) | 3.05(2.87) | 1.39(1.18) | 4.37(1.44) | 8.90(2.81) | <.001 | <.001 |
Cognitive symptom score,mean(SD) | 1.36(1.98) | 0.39(0.63) | 1.98(1.46) | 5.16(2.73) | <.001 | <.001 |
Somatic / Dep. symptom score,% | 69.2 | 78.1 | 68.9 | 63.3 | Â | Â |