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Table 4 Antidepressant outcomes in k = 8 DTMS studies with H1-coil and k = 11 rTMS studies with F8-coil

From: Antidepressant outcomes of high-frequency repetitive transcranial magnetic stimulation (rTMS) with F8-coil and deep transcranial magnetic stimulation (DTMS) with H1-coil in major depression: a systematic review and meta-analysis

Study

Response rate (session 10)

Remission definition

Remission rate (session 10)

Scale

Baseline daily phase; Mean ± SD (n)

Session 10 daily phase; Mean ± SD (n)

DTMS (H1-coil)

 Levkovitz et al., 2009 [15]a,b

45% (9/20)

HDRS≤10

20% (4/20)

HDRS24

31 ± 5 (20)

19 ± 8 (20)

 Rosenberg et al., 2010 [16]

29% (2/7)

HDRS≤10

14% (1/7)

HDRS24

27 ± 4 (7)

18 ± 6 (7)

 Rosenberg et al., 2010 [17]

50% (3/6)

HDRS≤10

17% (1/6)

HDRS24

31 ± 4 (6)

17 ± 7 (6)

 Isserles et al., 2011 [18]c

–

–

–

HDRS24

29 ± 6 (20)

16 ± 4 (20) completers

 Harel et al., 2014 [19]b

–

–

–

HDRS21

23 ± 4 (29)

17 ± 3 (26) completers

 Levkovitz et al., 2015 [9]b,d

15% (13/89)

HDRS≤10

7% (6/89)

HDRS21

24 ± 4 (89)

18 ± 6 (83)

 Rapinesi et al., 2015 [20]b

0%

HDRS≤10

11% (1/9)

HDRS21

24 ± 3 (9)

15 ± 3 (9)

 Rapinesi et al., 2015 [21]b,e

0%

HDRS≤7

0%

HDRS17

27 ± 6 (12)

22 ± 5 (12)

rTMS (F8-coil)

 George et al., 1997 [22]b,f

14% (1/7)

HDRS≤10

14% (1/7)

HDRS21

30 ± 4 (7)

23 ± 9 (7)

 Berman et al., 2000 [23]b,d

10% (1/10)

HDRS≤10

10% (1/10)

HDRS25

37 ± 10 (10)

25 ± 9 (10)

 Catafau et al., 2001 [24]b

40% (2/5)

HDRS≤7

0%

HDRS17

22 ± 4 (5)

19 ± 9 (5)

 Garcia-Toro et al., 2001 [25]b,d

–

–

–

HDRS21

27 ± 7 (17)

20 ± 6 (17)

 Garcia-Toro et al., 2001 [26]d

36% (4/11)

–

–

HDRS21

26 ± 6 (11)

16 ± 8 (11) completers

 Boutros et al., 2002 [27]d

25% (3/12)

HDRS≤10

8% (1/12)

HDRS25

41 ± 10 (12)

29 ± 14 (12) LOCF

 Bajbouj et al., 2005 [28]

33% (10/30)

–

–

HDRS24

26 ± 7 (30)

18 ± 9 (30)

 Yukimasa et al., 2006 [29]

19% (5/26)

HDRS≤7

27% (7/26)

HDRS17

21 ± 5 (26)

16 ± 7 (26)

 Luborzewski et al., 2007 [30]b

35% (6/17)

HDRS≤10

29% (5/17)

HDRS28

25 ± 7 (17)

19 ± 11 (17)

 Bakim et al., 2012 [31] 80%b,g

–

–

–

HDRS17

23 ± 4 (12)

16 ± 6 (12)

 Bakim et al., 2012 [31] 110%b,g

–

–

–

HDRS17

24 ± 3 (11)

17 ± 5 (11)

 Chen et al., 2013 [32]d

70% (7/10)

–

–

HDRS17

24 ± 2 (10)

10 ± 2 (10)

  1. Remission was defined as HDRS≤7 for HDRS-17 and HDRS≤10 for any other version of HDRS
  2. aData from H1–120% group (other groups were stimulated with different H-coil types). bData from unipolar MDD patients. cData from the control group ‘No cognitive-emotional reactivation’ (other groups received cognitive-emotional priming prior to DTMS). dData from the active stimulation group. eData from MDD group without alcohol use disorders. fData from the active rTMS group at week 2, phase 1 (before cross-over). gData from two independent groups who received active rTMS with different resting motor thresholds: 80% or 110%
  3. Abbreviations: DTMS deep transcranial magnetic stimulation, F8 figure-of-eight coil (rTMS), H1 H1-coil (DTMS), HDRS Hamilton Depression Rating Scale, k number of studies, LOCF last observation carried forward, n sample size, rTMS repetitive transcranial magnetic stimulation, SD standard deviation