Family-based association study of ZNF804A polymorphisms and autism in a Han Chinese population

BMC Psychiatry

Table 3 Haplotype-based association analyses between rs1344706 and rs7603001 in ZNF804A in 640 Han Chinese autism trios

Marker	Haplotype	Freq	Fam	S-E(S)	Var(S)	Z	P	Global P	Ppermutation^a
rs7603001-rs1344706	G-C	0.414	212	15.92	72.89	1.864	0.062	0.100	0.089
	A-A	0.305	285	−14.08	83.76	−1.539	0.124
	G-A	0.276	207	−0.42	65.90	−0.051	0.959
	A-C	0.006	4	n/a	n/a	n/a	n/a

Abbreviations: Freq, Estimation of haplotype frequencies; Fam, number of informative families; S, test statistics for the observed number of transmitted alleles; E(S), expected value of S under the null hypothesis (i.e., no linkage and no association); n/a: not applicable
^a Whole marker permutation test was performed using chisq sum P value (n = 10,000)

ISSN: 1471-244X