Table 2 Type and prevalence of comorbid chronic conditions in the study population with and without AD use
Total N (%) | With AD use N (%) | Without AD use N (%) | χ2 (df) | P | |
|---|---|---|---|---|---|
Chronic conditions | |||||
Acid related disorders | 231,616 (19.8) | 50,245 (47.6) | 181,371 (17.0) | 56,306 (1) | < 0.001a |
Bone diseases (osteoporosis) | 21,143 (1.8) | 5007 (4.7) | 16,136 (1.5) | 5618.5 (1) | < 0.001a |
Cancer | 15,955 (1.4) | 3076 (2.9) | 12,879 (1.2) | 2064.2 (1) | < 0.001a |
Cardiovascular diseases (incl. hypertension) | 279,956 (23.9) | 52,975 (50.1) | 226,981 (21.3) | 43,782 (1) | < 0.001a |
Dementia | 20,062 (1.7) | 6808 (6.4) | 13,254 (1.2) | 15,395 (1) | < 0.001a |
Diabetes mellitus | 56,381 (4.8) | 10,877 (10.3) | 45,504 (4.3) | 7581.5 (1) | < 0.001a |
Epilepsy | 33,742 (2.9) | 13,474 (12.8) | 20,268 (1.9) | 40,354 (1) | < 0.001a |
Glaucoma | 38,163 (3.3) | 6719 (6.4) | 31,444 (3.0) | 3525.2 (1) | < 0.001a |
Gout, Hyperuricemia | 18,380 (1.6) | 2818 (2.7) | 15,562 (1.5) | 900.13 (1) | < 0.001a |
HIV | 2365 (0.2) | 417 (0.4) | 1948 (0.2) | 212.07 (1) | < 0.001a |
Hyperlipidemia | 125,564 (10.7) | 23,948 (22.7) | 101,616 (9.6) | 17,242 (1) | < 0.001a |
Intestinal inflammatory diseases | 5144 (0.4) | 1135 (1.1) | 4009 (0.4) | 1065.7 (1) | < 0.001a |
Iron deficiency anemia | 56,746 (4.9) | 10,527 (10.0) | 46,219 (4.3) | 6570.1 (1) | < 0.001a |
Migraines | 12,958 (1.1) | 3252 (3.1) | 9706 (0.9) | 4110.9 (1) | < 0.001a |
Pain | 106,865 (9.1) | 29,862 (28.3) | 77,003 (7.2) | 51,163 (1) | < 0.001a |
Parkinson’s disease | 10,846 (0.9) | 4233 (4.0) | 6613 (0.6) | 11,979 (1) | < 0.001a |
Psychoses | 35,061 (3.0) | 19,466 (18.4) | 15,595 (1.5) | 95,027 (1) | < 0.001a |
Respiratory illness (asthma, COPD) | 99,180 (8.5) | 16,164 (15.3) | 83,016 (7.8) | 6954.1 (1) | < 0.001a |
Rheumatologic conditions | 138,197 (11.8) | 29,732 (28.1) | 108,465 (10.2) | 29,694 (1) | < 0.001a |
Thyroid disorders | 44,201 (3.8) | 10,161 (9.6) | 34,040 (3.2) | 10,880 (1) | < 0.001a |
Tuberculosis | 883 (0.1) | 169 (0.2) | 714 (0.1) | 108.55 (1) | < 0.001a |