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Table 3 Adjusted differences for HRQoL among respondents with TRD or nTRD compared to general population controls

From: The humanistic and economic burden of treatment-resistant depression in Europe: a cross-sectional study

Parameters

General population controls versus

TRDa

nTRDa

Adjusted difference

(LCL to UCL)

Adjusted difference

(LCL to UCL)

EQ-5D Index

−0.329 (−0.343 to −0.315)

−0.173 (−0.180 to −0.166)

Health Status, EQ VAS

−27.440 (−28.981 to −25.900)

−16.724 (−17.489 to −15.959)

MCS

−18.145 (−18.810 to −17.479)

−12.151 (−12.481 to −11.820)

PCS

−5.362 (−5.978 to −4.745)

−2.507 (− 2.813 to − 2.201)

SF-12 Bodily Pain

−8.771 (−9.503 to −8.039)

− 5.142 (− 5.506 to − 4.779)

SF-12 General Health

−11.414 (− 12.053 to −10.775)

−6.659 (−6.976 to −6.342)

SF-12 Mental Health

−15.781 (− 16.441 to − 15.121)

−10.473 (− 10.800 to − 10.145)

SF-12 Physical Functioning

−7.104 (−7.743 to − 6.465)

−3.762 (− 4.080 to −3.445)

SF-12 Role Emotional

−17.510 (− 18.299 to − 16.722)

− 11.374 (− 11.766 to − 10.983)

SF-12 Role Physical

−9.523 (− 10.198 to − 8.848)

− 5.619 (− 5.954 to − 5.284)

SF-12 Social Functioning

−14.963 (− 15.635 to − 14.290)

− 9.532 (− 9.866 to − 9.198)

SF-12 Vitality

−11.458 (− 12.149 to − 10.767)

− 7.335 (− 7.678 to − 6.992)

  1. EQ-5D EuroQol-5D, EQ VAS EuroQol Visual analogue scale, HRQoL health-related quality of life, LCL lower confidence interval, MCS mental component summary score, nTRD non-treatment resistant depression, PCS physical component summary score, SD standard deviation, SF-12 Medical Outcomes Study 12-Item Short Form Survey Instrument version 2, TRD treatment resistant depression, UCL upper confidence interval
  2. aGeneralized linear models were used adjusted for sociodemographic and health status variables. Comparisons versus the general population were statistically significant at p ≤ 0.001