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Table 2 MRI sequence parameters and additional recordings

From: The biological classification of mental disorders (BeCOME) study: a protocol for an observational deep-phenotyping study for the identification of biological subtypes

Paradigm
Measurement
Sequence detailsAdditional recordings
Day 1
#1 High resolution T1-weighted imageLOC
Sagittal FSPGR 3D BRAVO, TE 2.3 ms, TR 6.2 ms, TI 450 ms, FA 12°, FOV 25.6 × 25.6 × 20.0 cm3, matrix 256 × 256 × 200, FDir S/I (7.2 min)None
#2 Resting state functional MRI (rs-fMRI)2D Gradient Echo EPI, oblique, AC-PC alignment, FA 90°, TE 30.0 ms, TR 2.5 s, interleaved/ bottom-up, no dummy scans, FOV 24.0 × 24.0 cm2, ST 3.0 mm, SP 0.5 mm, 42 slices, matrix 96 × 96, FDir R/L, acceleration factor 2, 155 volumes (6.5 min)Eyetracking/ pupillo-metry, respiration belt, PPG
#3 EPI image with high tissue contrast2D Spin Echo EPI, same geometry as #2, TE 37.6 ms, TR 10 s, FOV 24.0 × 24.0 cm2, ST 2.5 mm, SP 0.5 mm, matrix 96 × 96, FDir R/L, acceleration factor 2, no dummy scans, 2 volumes (0.7 min)none
#4 Time estimation taskAs #2, 224 volumes (9.3 min)Eyetracking/ pupillo-metry,respiration belt, PPG
#5 FLAIR2D axial Fluid Attenuated Inversion Recovery, TE 160 ms, TR 11 s, TI 2250 ms, refocusing FA 111°, FOV 22.0 × 22.0 cm2, ST 4.0 mm, SP 0.8 mm, matrix 352 × 224, FDir A/P (4.4 min)none
#6 Reward anticipation taskAs #2, 230 volumes (9.5 min)Eyetracking/ pupillometry, respiration belt, PPG
#7 Whole brain Diffusion Tensor Imaging (DTI)2D Spin Echo DTI, TE 60.9 ms, TR 8 s, interleaved/ bottom-up, 66 diffusion directions, 5 initial B0 images, FOV 25.6 × 25.6 cm2, ST 2.0 mm, SP 0 mm, 60 slices, matrix 128 × 128, Fat Saturation
B0 images repeated using an inverted phase sampling for later unwarping of geometric distortions (9.6 min)
none
#8 Verbal n-back taskAs #2, 200 volumes (8.3 min)Eyetracking/ pupillo-metry, respiration belt, PPG
Day 2
#9 Face matching taskLOC
As #2, 230 volumes (9.6 min)Eyetracking/ pupillometry
#10 EPI image with high tissue contrastAs #3 (0.7 min)none
#11 rs-fMRIAs #2 (6.5 min)Eyetracking/ pupillometry
#12 Imaging stress test (IST)Gradient Echo, oblique, AC-PC alignment, FA 90°, TE 20.0 ms, TR 2.0 s, interleaved/bottom-up, no dummy images, FOV 24.0 × 24.0 cm2, ST 3.0 mm, SP 0.5 mm, 40 slices, matrix 96 × 96, FDir R/L, acceleration factor 2, 760 volumes (25.3 min)Skin conductance level, pulse, PPG, ECG, repeated blood samples
#13 rs-fMRILOCAs #2 (6.5 min)none
  1. Abbreviations: AC-PC anterior/posterior commissure, A/P anterior/posterior, ECG electrocardiogram, EPI echo planar imaging, FA flip angle, FDir frequency encoding direction, FOV field of view, IR inversion recovery, LOC sequence preceded by 3-plane localizer, including new pre-adjustments, min minutes, PPG pulse plethysmography, R/L right/left, S/I superior/inferior, SP slice spacing, ST slice thickness, TE time of echo, TI inversion recovery time, TR time of repetition; (duration in minutes)