Table 3 Research questions- substance (drug and/ or alcohol) use disorders

For people with SMD and substance (drug and/or alcohol) use disorder, are pharmacological and/or non-pharmacological interventions for substance use disorder effective to support reduction in substance use-related outcomes?

Population/ Intervention / Comparison / Outcome (PICO)

Population: people with SMD and substance (drug and/or alcohol) use disorder

Intervention:

pharmacological and/or non-pharmacological interventions for substance use disorders:

- Pharmacological interventions

- Non-pharmacological interventions: e.g. motivational interviewing and/or CBT, psychoeducation, brief assessment interview, dual-focus interventions

Comparison: care as usual / placebo or one treatment vs another

Outcomes:

Critical

- Level of consumption

- Frequency of use

- Abstinence

- Relapse rates

Important:

- Frequency of adverse events / side-effects