| Outcome | N (% of DPs granted) | Unadjusted HR (95% CI) | Adjusted HR (95% CI)b |
|---|
| All-cause DP |
| Comparatorsa (n = 3204) | 406 (100) | Ref | Ref |
| TRD (n = 3204) | 730 (100) | 1.90 (1.72–2.11) | 2.07 (1.83–2.35) |
| DP due to mental and behavioural disorders |
| Comparators | 309 (76.1) | Ref | Ref |
| TRD | 621 (85.1) | 2.13 (1.89–2.39) | 2.24 (1.95–2.57) |
| Of which DP due to depression (F32–33) |
| Comparators | 134 (43.4) | Ref | Ref |
| TRD | 277 (44.6) | 2.15 (1.80–2.56) | 2.28 (1.82–2.85) |
| DP due to somatic disorders |
| Comparators | 97 (23.9) | Ref | Ref |
| TRD | 109 (14.9) | 1.22 (0.98–1.51) | 1.25 (0.84–1.86) |
- aComparators matched on age, sex, calendar year of the index prescription, history of depression, and size of living area
- bAdjusted for attained educational level, marital/ parental status, country of birth, long-term sickness absence, unemployment, anxiety, personality and other psychiatric disorders, substance use disorder, history of self-harm/suicide attempt and Charlson’s Comorbidity index
