Risk and risk factors for disability pension among patients with treatment resistant depression– a matched cohort study

Table 2 Risk for disability pension (DP) among patients with treatment-resistant depression (TRD) vs. matched comparators with treatment for depression. Unadjusted and adjusted hazard ratios (HR) with 95% confidence intervals (CI) for all-cause and cause-specific DP

Outcome	N (% of DPs granted)	Unadjusted HR (95% CI)	Adjusted HR (95% CI)^b
All-cause DP
Comparators^a (n = 3204)	406 (100)	Ref	Ref
TRD (n = 3204)	730 (100)	1.90 (1.72–2.11)	2.07 (1.83–2.35)
DP due to mental and behavioural disorders
Comparators	309 (76.1)	Ref	Ref
TRD	621 (85.1)	2.13 (1.89–2.39)	2.24 (1.95–2.57)
Of which DP due to depression (F32–33)
Comparators	134 (43.4)	Ref	Ref
TRD	277 (44.6)	2.15 (1.80–2.56)	2.28 (1.82–2.85)
DP due to somatic disorders
Comparators	97 (23.9)	Ref	Ref
TRD	109 (14.9)	1.22 (0.98–1.51)	1.25 (0.84–1.86)

^aComparators matched on age, sex, calendar year of the index prescription, history of depression, and size of living area
^bAdjusted for attained educational level, marital/ parental status, country of birth, long-term sickness absence, unemployment, anxiety, personality and other psychiatric disorders, substance use disorder, history of self-harm/suicide attempt and Charlson’s Comorbidity index

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