Table 1 Demographic and clinical data of patients with possible iNPH and without iNPH (no iNPH)
Characteristics | No iNPH (n = 33) | Possible iNPH (n = 5) | p value |
|---|---|---|---|
Sex, male | 21 | 4 | 0.643 |
Age (years) | 68.3 ± 7.4 | 72.2 ± 9.6 | 0.352 |
BMI (kg/m2) | 21.5 ± 2.3 (29) | 23.4 ± 2.7 (4) | 0.133 |
Smoking | 9 | 0 | 0.555 |
Hypertension | 7 | 1 | 1.0 |
Hyperlipidemia | 9 | 1 | 1.0 |
Diabetes Mellitus | 1 | 0 | 1.0 |
Age of onset (years) | 23.2 ± 8.1 | 24.8 ± 7.3 | 0.632 |
Duration of illness (months) | 45.0 ± 7.9 | 47.4 ± 13.2 | 0.436 |
CP equivalent | 820.9 ± 500.9 | 741.2 ± 591.4 | 0.863 |
Drug administration | |||
 Anticholinergics | 10 | 2 | 1.0 |
 Benzodiazepines | 23 | 2 | 0.342 |
 Antidepressants | 0 | 0 | – |
 Mood stabilizers | 13 | 0 | 0.342 |
 PANSS–total | 89.4 ± 15.4 | 87.0 ± 18.9 | 0.931 |
 PANSS–positive | 21.6 ± 5.1 | 18.4 ± 5.7 | 0.363 |
 PANSS–negative | 24.3 ± 6.9 | 24.8 ± 7.0 | 0.914 |
 PANSS–general | 43.5 ± 9.2 | 43.8 ± 6.7 | 0.762 |
 DIEPSS | 5.8 ± 5.0 | 10.4 ± 5.0 | 0.062 |
iNPHGS | |||
 GS-Gait | 0.91 ± 1.2 | 2.2 ± 1.8 | 0.082 |
 GS-Cogn | 1.9 ± 1.2 | 2.4 ± 1.5 | 0.471 |
 GS-Urin | 1.0 ± 1.6 | 1.6 ± 1.8 | 0.425 |
 TUG | 14.7 ± 6.6 (26) | 10.6 ± 2.7 (3) | 0.267 |
 10-m walking test | 14.0 ± 4.9 (26) | 15.3 ± 7.3 (3) | 0.858 |
 GSS | 3.2 ± 3.1 (29) | 5.0 ± 2.6 (3) | 0.192 |
 MMSE | 19.6 ± 6.3 (31) | 15.6 ± 8.3 | 0.281 |
 NPI | 15.4 ± 11.4 | 8.0 ± 7.9 | 0.160 |
 Evans’ Index | 0.27 ± 0.04 | 0.34 ± 0.03 | 0.002 |
 DESH | 2 | 4 | <  0.001 |
APOE ε4+/ε4− | 8/25 | 1/4 | 1.0 |