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Table 3 Results of the case/non-case analysis to identify an increased reporting risk of movement disorder for each of the 9 movement disorders for all antidepressants compared to all other drugs in VigiBase®

From: Antidepressants and movement disorders: a postmarketing study in the world pharmacovigilance database

  Case Non-case Total Crude ROR [95% CI] p
Akathisia
 58 antidepressants 2160 1,025,245 1,027,405 3.79 [3.61–3.98] <.0001
 All other drugs in VigiBase® 7359 13,235,682 13,243,041
 Total 9519 14,260,927 14,270,446
Bruxism
 58 antidepressants 1244 1,026,161 1,027,405 10.37 [9.62–11.17] <.0001
 All other drugs in VigiBase® 1548 13,241,493 13,243,041
 Total 2792 14,267,654 14,270,446
Dystonia
 58 antidepressants 5113 1,022,292 1,027,405 2.07 [2.01–2.14] <.0001
 All other drugs in VigiBase® 31,870 13,211,171 13,243,041
 Total 36,983 14,233,463 14,270,446
Myoclonus
 58 antidepressants 1944 1,025,461 1,027,405 4.79 [4.55–5.05] <.0001
 All other drugs in VigiBase® 5237 13,237,804 13,243,041
 Total 7181 14,263,265 14,270,446
Parkinsonism
 58 antidepressants 3695 1,023,710 1,027,405 2.14 [2.07–2.22] <.0001
 All other drugs in VigiBase® 22,289 13,220,752 13,243,041
 Total 25,984 14,244,462 14,270,446
Restless legs syndrome
 58 antidepressants 2430 1,024,975 1,027,405 5.14 [4.90–5.38] <.0001
 All other drugs in VigiBase® 6111 13,236,930 13,243,041
 Total 8541 14,261,905 14,270,446
Tardive dyskinesia
 58 antidepressants 2598 1,024,807 1,027,405 1.55 [1.49–1.61] <.0001
 All other drugs in VigiBase® 21,625 13,221,416 13,243,041
 Total 24,223 14,246,223 14,270,446
Tics
 58 antidepressants 770 1,026,635 1,027,405 1.49 [1.38–1.60] <.0001
 All other drugs in VigiBase® 6667 13,236,374 13,243,041
 Total 7437 14,263,009 14,270,446
Tremor
 58 antidepressants 28,021 999,384 1,027,405 3.06 [3.02–3.10] <.0001
 All other drugs in VigiBase® 120,400 13,122,641 13,243,041
 Total 148,421 14,122,025 14,270,446
  1. ROR, reporting odds ration; CI, confident interval