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Table 3 Results of the case/non-case analysis to identify an increased reporting risk of movement disorder for each of the 9 movement disorders for all antidepressants compared to all other drugs in VigiBase®

From: Antidepressants and movement disorders: a postmarketing study in the world pharmacovigilance database

 

Case

Non-case

Total

Crude ROR [95% CI]

p

Akathisia

 58 antidepressants

2160

1,025,245

1,027,405

3.79 [3.61–3.98]

<.0001

 All other drugs in VigiBase®

7359

13,235,682

13,243,041

 Total

9519

14,260,927

14,270,446

Bruxism

 58 antidepressants

1244

1,026,161

1,027,405

10.37 [9.62–11.17]

<.0001

 All other drugs in VigiBase®

1548

13,241,493

13,243,041

 Total

2792

14,267,654

14,270,446

Dystonia

 58 antidepressants

5113

1,022,292

1,027,405

2.07 [2.01–2.14]

<.0001

 All other drugs in VigiBase®

31,870

13,211,171

13,243,041

 Total

36,983

14,233,463

14,270,446

Myoclonus

 58 antidepressants

1944

1,025,461

1,027,405

4.79 [4.55–5.05]

<.0001

 All other drugs in VigiBase®

5237

13,237,804

13,243,041

 Total

7181

14,263,265

14,270,446

Parkinsonism

 58 antidepressants

3695

1,023,710

1,027,405

2.14 [2.07–2.22]

<.0001

 All other drugs in VigiBase®

22,289

13,220,752

13,243,041

 Total

25,984

14,244,462

14,270,446

Restless legs syndrome

 58 antidepressants

2430

1,024,975

1,027,405

5.14 [4.90–5.38]

<.0001

 All other drugs in VigiBase®

6111

13,236,930

13,243,041

 Total

8541

14,261,905

14,270,446

Tardive dyskinesia

 58 antidepressants

2598

1,024,807

1,027,405

1.55 [1.49–1.61]

<.0001

 All other drugs in VigiBase®

21,625

13,221,416

13,243,041

 Total

24,223

14,246,223

14,270,446

Tics

 58 antidepressants

770

1,026,635

1,027,405

1.49 [1.38–1.60]

<.0001

 All other drugs in VigiBase®

6667

13,236,374

13,243,041

 Total

7437

14,263,009

14,270,446

Tremor

 58 antidepressants

28,021

999,384

1,027,405

3.06 [3.02–3.10]

<.0001

 All other drugs in VigiBase®

120,400

13,122,641

13,243,041

 Total

148,421

14,122,025

14,270,446

  1. ROR, reporting odds ration; CI, confident interval