Table 1 Literature review of brain regions with significant change in neural activity for obsessive-compulsive disorder (OCD) patients before and after psychotherapy. Please note that this list only includes task-related fMRI studies
Brain region | Change during psychotherapy ↑ increase or ↓ decrease | |
|---|---|---|
executive tasks | symptom provocation | |
amygdala |  | ↑ Olatunji et al. [15] |
anterior cingulate cortex | ↑ Huyser et al. [16] ↑ Verfaillie et al. [17] | ↓ Morgiève et al. [18] ↓ Schiepek et al. [13] ↓ Nakao et al. [19] |
anterior temporal pole |  | ↑ Olatunji et al. [15] |
cerebellum | ↑ Nakao et al. [19] ↑ Nabeyama et al. [20] | ↓ Nakao et al. [19] |
cuneus |  | ↓ Schiepek et al. [13] |
fusiform gyrus | ↓ Nabeyama et al. [20] |  |
hippocampus | ↓ Nakao et al. [19] |  |
insula | ↓ Lázaro et al. [21] ↓ van der Straten et al. [22] | ↓ Schiepek et al. [13] |
middle cingulate cortex | ↓ Nakao et al. [19] |  |
middle frontal cortex | ↓ Nabeyama et al. [20] ↓ Nakao et al. [19] |  |
nucleus accumbens |  | ↓ Baioui et al. [23] |
nucleus caudatus | ↑ Freyer et al. [24] ↑ Verfaillie et al. [17] | ↓ Baioui et al. [23] |
occipital cortex | ↓ Nakao et al. [19] | ↓ Nakao et al. [19] |
orbitofrontal cortex | ↓ Nabeyama et al. [20] | ↓ Baioui et al. [23] ↓ Morgiève et al. [18] ↓ Nakao et al. [19] |
parahippocampus | ↓ Nabeyama et al. [20] |  |
parietal cortex | ↑ Nakao et al. [19] | ↓ Schiepek et al. [13] |
precuneus | ↓ Nabeyama et al. [20]a ↑ Nabeyama et al. [20]b |  |
prefrontal cortex | ↑ Huyser et al. [16] ↑ Nakao et al. [19] | ↓ Baioui et al. [23] ↓ Schiepek et al. [13] |
premotor region | ↑ Huyser et al. [16] |  |
putamen | ↓ Freyer et al. [24] ↓ Lázaro et al. [21] ↑ Nakao et al. [19] ↑ Verfaillie et al. [17] | ↓ Nakao et al. [19] |
supramarginal gyrus |  | ↓ Baioui et al. [23] |
temporal cortex (middle and superior) | ↑ Nakao et al. [19]a ↓ Nakao et al. [19]b | ↓ Nakao et al. [19] |
thalamus |  | ↓ Nakao et al. [19] |