| OCD (n = 250) | Unaffected Siblings (n = 100) | Healthy Controls (n = 250) |
---|---|---|---|
Inclusion Criteria | • 18–50 years old • Principal diagnosis of OCD • YBOCS ≥16 | • 18–50 years old • Has sibling with OCD | • 18–50 years old |
Exclusion Criteria | • Lifetime diagnosis of psychosis, bipolar disorder, anorexia, autism, or Tourette disorder • Current chronic tic disorder, substance-use disorder, binge-eating disorder, bulimia, or suicidality • Current use of psychotropic medications or CBT for OCD | • Current or lifetime psychiatric disorder other than MDD or anxiety disorders • Current use of psychotropic medications | • Current or lifetime psychiatric disorder other than MDD or anxiety disorders (if not in past year) • Current or past use of psychotropic medications • First-degree relative with OCD or tic disorder |
• Major medical or neurological diseases • IQ < 80 • Contraindications to MRI |