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Table 1 Inclusion and Exclusion Criteria

From: Toward identifying reproducible brain signatures of obsessive-compulsive profiles: rationale and methods for a new global initiative

 

OCD (n = 250)

Unaffected Siblings (n = 100)

Healthy Controls (n = 250)

Inclusion Criteria

• 18–50 years old

• Principal diagnosis of OCD

• YBOCS ≥16

• 18–50 years old

• Has sibling with OCD

• 18–50 years old

Exclusion Criteria

• Lifetime diagnosis of psychosis, bipolar disorder, anorexia, autism, or Tourette disorder

• Current chronic tic disorder, substance-use disorder, binge-eating disorder, bulimia, or suicidality

• Current use of psychotropic medications or CBT for OCD

• Current or lifetime psychiatric disorder other than MDD or anxiety disorders

• Current use of psychotropic medications

• Current or lifetime psychiatric disorder other than MDD or anxiety disorders (if not in past year)

• Current or past use of psychotropic medications

• First-degree relative with OCD or tic disorder

• Major medical or neurological diseases

• IQ < 80

• Contraindications to MRI

  1. OCD Obsessive-compulsive disorder, YBOCS Yale-Brown Obsessive-Compulsive Severity Scale, CBT Cognitive-behavioral therapy, IQ Intelligence quotient, MRI Magnetic resonance imaging, MDD Major depressive disorder