Fig. 2

Conditional power. Box plots illustrating conditional power (CP) across all comparisons with inconclusive evidence as a function of sample size with respect to the two outcomes efficacy and tolerability. Whiskers of the box plots extend to the most extreme data values. Horizontal red dashed lines indicate 20% and 80% conditional power at which sample sizes (N_CP=20%, N_CP=80%) were estimated. Results are shown based on the main analysis considering a trial design ratio of r = 1/0, anticipated alternative effect sizes equal to the network estimates (f_xyN), and anticipated event probabilities equal to the average network event probability (pc_N)