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Table 1 Demographic and clinical data (N = 27)

From: Cortical haemodynamic response during the verbal fluency task in patients with bipolar disorder and borderline personality disorder: a preliminary functional near-infrared spectroscopy study

 

HC

BD

BPD

p-value

Age (years)

33.4 ± 10.2

34.6 ± 10.4

34 ± 9.9

0.974

Ethnicity

   

1.00

 Chinese

8 (88.9%)

8 (88.9%)

8 (88.9%)

 

 Indian

1 (11.1%)

1 (11.1%)

1 (11.1%)

 

Education (years)

16 ± 1.5

16 ± 2.1

14 ± 2.1

0.059

Handedness a

   

0.258

 Right

9 (100%)

5 (71.4%)

8 (100%)

 

 Left

0

1 (14.3%)

0

 

 Ambidextrous

0

1 (14.3%)

0

 

Number of words a

16.8 ± 4.1

15.4 ± 4.3

16 ± 5

0.813

Family history of psychiatric illness a

2 (25%)

4 (50%)

4 (44.4%)

0.561

Age at illness onset (years)

–

25.3 ± 8.1

23.9 ± 9.3

0.729

Duration of illness (years)

–

9.2 ± 8.1

10.1 ± 6.6

0.802

Past admission into psychiatric ward

–

7 (77.8%)

8 (88.9%)

0.500

GAF score b

93.3 ± 8.7

71.1 ± 12.7

62.2 ± 9.7

≤0.001

HAM-D score a, b

2.9 ± 2.5

11.3 ± 6.3

16.1 ± 5.3

≤0.001

YMRS score a

–

2.1 ± 3.4

–

–

BPQ score

–

31 ± 22.7

57.7 ± 5.1

0.176

Pharmacotherapy

–

9 (100%)

9 (100%)

–

 Antidepressants

–

4 (44.4%)

9 (100%)

0.029

 Anxiolytics & sedatives

–

4 (44.4%)

2 (22.2%)

0.310

 Antipsychotics

–

3 (33.3%)

2 (22.2%)

0.500

 Mood stabilisers

–

6 (66.7%)

5 (55.6%)

0.500

 Fluoxetine eq. dose (mg/day)

–

44 ± 30.2

29.3 ± 17.3

0.282

 Diazepam eq. dose (mg/day)

–

12.1 ± 9.7

7.1 ± 4.1

0.540

 Chlorpromazine eq. dose (mg/day)

–

244 ± 139.3

303 ± 214.3

0.726

  1. Mean ± SD are shown and p-values ≤0.05 are in bold.
  2. a Complete demographic and clinical data were not obtained for all subjects (Known handedness in healthy controls, n = 9; patients with bipolar disorder, n = 7; patients with borderline personality disorder, n = 8. Known number of words in healthy controls, n = 9; patients with bipolar disorder, n = 8; patients with borderline personality disorder, n = 9. Known family history of psychiatric disorder in healthy controls, n = 8; patients with bipolar disorder, n = 9; patients with borderline personality disorder, n = 9. Known HAM-D score in healthy controls, n = 9; patients with bipolar disorder, n = 8; patients with borderline personality disorder, n = 9. Known YMRS score in patients with bipolar disorder, n = 7. Known BPQ score in patients with bipolar disorder, n = 3; patients with borderline personality disorder, n = 9.)
  3. b Post-hoc test showed statistically significant differences in GAF and HAM-D scores between healthy controls and patients with bipolar disorder (GAF, p ≤ 0.001; HAM-D, p = 0.006) and between healthy controls and patients with borderline personality disorder (p ≤ 0.001), but not between patient groups (GAF, p = 0.255; HAM-D, p = 0.159)