Table 2 Reason for discontinuation and the timing
Reason for discontinuationa | Timing of discontinuation, n (%) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Total | Day 1- < 29 | Day 29- < 61 | Day 61- < 91 | Day 91- < 121 | Day 121- < 181 | Day 181- < 270 | Day 270- < 365 | Day ≥365 | |
1. Adverse events | 43 (21.4) | 12 (6.0) | 9 (4.5) | 4 (2.0) | 4 (2.0) | 5 (2.5) | 7 (3.5) | 2 (1.0) | 0 (0.0) |
2. Worsening of symptoms | 14 (7.0) | 2 (1.0) | 2 (1.0) | 1 (0.5) | 1 (0.5) | 2 (1.0) | 3 (1.5) | 3 (1.5) | 0 (0.0) |
3. Improved symptoms | 32 (15.9) | 4 (2.0) | 1 (0.5) | 5 (2.5) | 4 (2.0) | 3 (1.5) | 8 (4.0) | 6 (3.0) | 1 (0.5) |
4. Request for discontinuation from patient or family | 68 (33.8) | 14 (7.0) | 13 (6.5) | 5 (2.5) | 5 (2.5) | 7 (3.5) | 13 (6.5) | 9 (4.5) | 2 (1.0) |
5.Transfer to another hospital | 21 (10.4) | 2 (1.0) | 4 (2.0) | 0 (0.0) | 0 (0.0) | 7 (3.5) | 4 (2.0) | 4 (2.0) | 0 (0.0) |
6. Lost to follow-up | 38 (18.9) | 7 (3.5) | 7 (3.5) | 3 (1.5) | 4 (2.0) | 5 (2.5) | 7 (3.5) | 5 (2.5) | 0 (0.0) |
7. Other | 15 (7.5) | 2 (1.0) | 1 (0.5) | 0 (0.0) | 2 (1.0) | 7 (3.5) | 2 (1.0) | 0 (0.0) | 1 (0.5) |
Totalb | 201 (100.0) | 37 (18.4) | 34 (16.9) | 16 (8.0) | 17 (8.5) | 30 (14.9) | 39 (19.4) | 24 (11.9) | 4 (2.0) |