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Table 3 Distribution of putative Etiological Variables for level of outcome (n = 47,004)

From: Testing extra-linearity across a psychosis continuum

 

PEs level1

N = 13,978 (29·7%)

PEs level2

N = 23,567 (50·1%)

PEs level3

N = 6402 (13·6%)

PEs level4

N = 2118 (4·5%)

PEs level5

N = 939 (2·0%)

Deviation From Linearity

Mean

(SD)

β

Mean

(SD)

β

(95%CI)

Mean

(SD)

β

(95%CI)

Mean

(SD)

β

(95%CI)

Mean

(SD)

β

(95%CI)

βa

χ2

P-value

Demography

 Age

18·19

(SD 0·91)

18·23

(0·95)

0·00

(Ref)

18·18

(0·90)

−0·05***$

(− 0·06−− 0·03)

18·16

(0·88)

− 0·06***$

(− 0·09−− 0·04)

18·16

(0·87)

−0·07**$

(− 0·11–0·02)

18·17

(0·83)

−0·06

(− 0·12–0·00)

0·01

4·30

0·03

 

0·00

(Ref)

 

−0·07 ***$

(− 0·09−− 0·05)

 

−0·12***$

(− 0·15−− 0·09)

 

-0·15***$

(− 0·19--0·10)

 

-0·18***$

(− 0·24--0·11)

0·00

0·01

0·93

 

N (%)

OR

N (%)

OR (95%CI)

N (%)

OR (95%CI)

N (%)

OR (95%CI)

N (%)

OR (95%CI)

   

 Male

n = 23,444 (49·9%)

7353

(52·6)

1·00

(Ref)

11,313

(48·0)

0·83***$

(0·80–0·87)

3213

(50·2)

0·91**$

(0·86–0·96)

1096

(51·7)

0·97

(0·88–1·06)

469

(49·9)

0·90

(0·79–1·03)

0·06

42·18

< 0·001$

 

1·00

(Ref)

 

0·91***$

(0·91–0·95)

 

1·12***$

(1·05–1·20)

 

1·32***$

(1·19–1·47)

 

1·43***$

(1·23–1·66)

0·10

98·30

< 0·001$

 Ethnic Minority

n = 4777 (10·1%)

1358

(9·7)

1·00

(Ref)

2375

(10·1)

1·05

(0·98–1·13)

693

(10·8)

1·15**

(1·04–1·26)

248

(11·7)

1·26**$

(1·09–1·45)

103

(11·0)

1·16

(0·94–1·44)

0·02

1·69

0·19

 

1·00

(Ref)

 

0·99

(0·92–1·07)

 

0·99

(0·89–1·11)

 

1·01

(0·86–1·19)

 

0·84

(0·66–1·07)

0·00

0·01

0·91

 Low Family Income

n = 6986 (14·9%)

2047

(14·6)

1·00

(Ref)

3446

(14·6)

1·02

(0·96–1·08)

970

(15·1)

1·06

(0·98–1·16)

339

(16·0)

1·14*

(1·00–1·29)

184

(19·6)

1·46***$

(1·23–1·73)

0·04

8·72

0·003

 

1·00

(Ref)

 

0·95

(0·89–1·01)

 

0·89*

(0·81–0·98)

 

0·87 (0·75–1·00)

 

0·98

(0·80–1·19)

0·01

0·36

0·55

 Urban Birth

n = 6791 (14·4%)

2292

(16·4)

1·00

(Ref)

3221

(13·7)

0·80***$

(0·75–0·85)

835

(13·0)

0·76***$

(0·69–0·82)

318

(15·0)

0·89

(0·79–1·01)

125

(13·3)

0·78*

(0·64–0·94)

0·06

16·68

< 0·001$

 

1·00

(Ref)

 

0·87***$

(0·81–0·92)

 

0·92

(0·84–1·01)

 

1·19*

(1·03–1·38)

 

1·19

(0·96–1·48)

0·09

37·27

< 0·001$

 

PEs level1

N = 13,978 (29·7%)

PEs level2

N = 23,567 (50·1%)

PEs level3

N = 6402 (13·6%)

PEs level4

N = 2118 (4·5%)

PEs level5

N = 939 (2·0%)

Deviation From Linearity

N (%)

OR

N (%)

OR (95%CI)

N (%)

OR (95%CI)

N (%)

OR (95%CI)

N (%)

OR (95%CI)

βa

χ2

P-value

Family History

 Family History (psychosis)

n = 338 (0·7%)

67

(0·5)

1·00

(Ref)

159 (0·7)

1·40*

(1·05–1·86)

69

(1·1)

2·25***$

(1·60–3·15)

27

(1·3)

2·67***$

(1·70–4·18)

16

(1·7)

3·58***$

(2·06–6·19)

0·05

1·10

0·29

 

1·00

(Ref)

 

1·26

(0·94–1·69)

 

1·74**

(1·20–2·54)

 

1·82*

(1·09–3·05)

 

2·02*

(1·03–3·94)

0·10

0·03

0·86

 Family History (non-psychosis)

n = 440 (0·9%)

79

(0·6)

1·00

(Ref)

214 (0·9)

1·58***$

(1·22–2·05)

87

(1·4)

2·39***$

(1·76–3·25)

50

(2·3)

4·22***$

(2·95–6·03)

10

(1·1)

1·87

(0·97–3·62)

-0·01

0·01

0·91

 

1·00

(Ref)

 

1·42**

(1·09–1·85)

 

1·82***$

(1·29–2·55)

 

2·79***$

(1·83–4·25)

 

1·00

(0·48–2·11)

-0·05

1·06

0·30

Adverse Childhood Experiences

 Loss of Parent (Divorce)

n = 1102 (2·3%)

191

(1·3)

1·00

(Ref)

546

(2·3)

1·71***$

(1·45–2·02)

219

(3·4)

2·57***$

(2·11–3·12)

85

(4·0)

3·03***$

(2·34–3·94)

61

(6·0)

5·03***$

(3·74–6·77)

0·03

0·93

0·34

 

1·00

(Ref)

 

1·61***$

(1·36–1·91)

 

2·21***$

(1·78–2·74)

 

2·42***$

(1·80–3·25)

 

3·59***$

(2·50–5·16)

0·00

0·01

0·92

 Loss of Parent (Death)

n = 632 (1·3%)

145

(1·0)

1·00

(Ref)

304

(1·3)

1·25*

(1·02–1·53)

114

(1·8)

1·74***$

(1·36–2·23)

48

(2·2)

2·23***$

(1·60–3·10)

21

(2·2)

2·19***$

(1·38–3·49)

0·06

2·41

0·12

 

1·00

(Ref)

 

1·16

(0·94–1·42)

 

1·44**

(1·09–1·90)

 

1·68**

(1·15–2·45)

 

1·43

(0·83–2·46)

0·03

0·55

0·46

 Physical Abuse

n = 14,785 (31·5%)

3829

(27·4)

1·00

(Ref)

6773

(28·7)

1·09***$

(1·04–1·14)

2625

(41·0)

1·88***$

(1·76–2·00)

1019

(48·1)

2·49***$

(2·27–2·74)

539

(57·4)

3·66***$

(3·20–4·19)

0·17

253·88

< 0·001$

 

1·00

(Ref)

 

1·01

(0·96–1·06)

 

1·55***$

(1·44–1·66)

 

1·87***$

(1·68–2·08)

 

2·40***$

(2·06–2·80)

0·14

171·46

< 0·001$

 Sexual Abuse

n = 1360 (2·9%)

311

(2·2)

1·00

(Ref)

666

(2·8)

1·25**$

(1·09–1·43)

208

(3·2)

1·46***$

(1·22–1·75)

102

(4·8)

2·22***$

(1·77–2·79)

73

(7·8)

3·67***$

(2·82–4·78)

0·13

25·67

< 0·001$

 

1·00

(Ref)

 

1·12

(0·97–1·29)

 

1·11

(0·91–1·35)

 

1·46**

(1·13–1·90)

 

1·97***$

(1·42–2·74)

0·08

9·50

0·002$

 Neglect

n = 16,056 (34·2%)

3511

(25·1)

1·00

(Ref)

7707

(32·7)

1·46***$

(1·39–1·53)

3042

(45·7)

2·72***$

(2·55–2·89)

1198

(56·6)

3·90***$

(3·55–4·29)

598

(63·9)

5·27***$

(4·59–6·05)

0·12

128·09

< 0·001$

 

1·00

(Ref)

 

1·32***$

(1·25–1·38)

 

2·11***$

(1·97–2·27)

 

2·69***$

(2·42–2·99)

 

3·06***$

(2·62–3·57)

0·09

64·77

< 0·001$

  > =2 maltreatment

n = 10,567 (22.5%)

2991 (21.4)

1.00

(Ref)

4531 (19.2)

0.88***$

(0.84–0.93)

1811 (28.3)

1.46***$

(1.36–1.56)

790 (37.3)

2.20***$

(1.99–2.42)

444 (47.3)

3.33***$

(2.91–3.81)

0.24

434

< 0·001$

 

1.00

(Ref)

 

0.82***$

(0.77–0.86)

 

1.20***$

(1.11–1.29)

 

1.64***$

(1.47–1.83)

 

2.17***$

(1.85–2.53)

0.21

315.23

< 0·001$

  1. No adjustment for demographic variables· Adjusted for age and sex in the first row for the rest variables· Second row for each variable additionally adjusted for PHQ-9 score
  2. *P < 0·05, **p < 0·01, ***p < 0·001
  3. aregression coefficient for the squared term of PEs scores· A negative squared term suggests a qualitatively stronger association at the lower end of the PEs spectrum, and a positive squared term suggests a qualitatively stronger association at the higher end of the PEs spectrum. Significant deviation from linearity indicates a positive linear effect
  4. $: significance after correction for regressions of 21 variables using Bonferroni’s correction and the new threshold is 0.05/21 = 0.0024