| PEs level1 N = 13,978 (29·7%) | PEs level2 N = 23,567 (50·1%) | PEs level3 N = 6402 (13·6%) | PEs level4 N = 2118 (4·5%) | PEs level5 N = 939 (2·0%) | Deviation From Linearity | |||||||
Mean (SD) | β | Mean (SD) | β (95%CI) | Mean (SD) | β (95%CI) | Mean (SD) | β (95%CI) | Mean (SD) | β (95%CI) | βa | χ2 | P-value | |
Demography | |||||||||||||
 Age 18·19 (SD 0·91) | 18·23 (0·95) | 0·00 (Ref) | 18·18 (0·90) | −0·05***$ (− 0·06−− 0·03) | 18·16 (0·88) | − 0·06***$ (− 0·09−− 0·04) | 18·16 (0·87) | −0·07**$ (− 0·11–0·02) | 18·17 (0·83) | −0·06 (− 0·12–0·00) | 0·01 | 4·30 | 0·03 |
 | 0·00 (Ref) |  | −0·07 ***$ (− 0·09−− 0·05) |  | −0·12***$ (− 0·15−− 0·09) |  | -0·15***$ (− 0·19--0·10) |  | -0·18***$ (− 0·24--0·11) | 0·00 | 0·01 | 0·93 | |
 | N (%) | OR | N (%) | OR (95%CI) | N (%) | OR (95%CI) | N (%) | OR (95%CI) | N (%) | OR (95%CI) |  |  |  |
 Male n = 23,444 (49·9%) | 7353 (52·6) | 1·00 (Ref) | 11,313 (48·0) | 0·83***$ (0·80–0·87) | 3213 (50·2) | 0·91**$ (0·86–0·96) | 1096 (51·7) | 0·97 (0·88–1·06) | 469 (49·9) | 0·90 (0·79–1·03) | 0·06 | 42·18 | < 0·001$ |
 | 1·00 (Ref) |  | 0·91***$ (0·91–0·95) |  | 1·12***$ (1·05–1·20) |  | 1·32***$ (1·19–1·47) |  | 1·43***$ (1·23–1·66) | 0·10 | 98·30 | < 0·001$ | |
 Ethnic Minority n = 4777 (10·1%) | 1358 (9·7) | 1·00 (Ref) | 2375 (10·1) | 1·05 (0·98–1·13) | 693 (10·8) | 1·15** (1·04–1·26) | 248 (11·7) | 1·26**$ (1·09–1·45) | 103 (11·0) | 1·16 (0·94–1·44) | 0·02 | 1·69 | 0·19 |
 | 1·00 (Ref) |  | 0·99 (0·92–1·07) |  | 0·99 (0·89–1·11) |  | 1·01 (0·86–1·19) |  | 0·84 (0·66–1·07) | 0·00 | 0·01 | 0·91 | |
 Low Family Income n = 6986 (14·9%) | 2047 (14·6) | 1·00 (Ref) | 3446 (14·6) | 1·02 (0·96–1·08) | 970 (15·1) | 1·06 (0·98–1·16) | 339 (16·0) | 1·14* (1·00–1·29) | 184 (19·6) | 1·46***$ (1·23–1·73) | 0·04 | 8·72 | 0·003 |
 | 1·00 (Ref) |  | 0·95 (0·89–1·01) |  | 0·89* (0·81–0·98) |  | 0·87 (0·75–1·00) |  | 0·98 (0·80–1·19) | 0·01 | 0·36 | 0·55 | |
 Urban Birth n = 6791 (14·4%) | 2292 (16·4) | 1·00 (Ref) | 3221 (13·7) | 0·80***$ (0·75–0·85) | 835 (13·0) | 0·76***$ (0·69–0·82) | 318 (15·0) | 0·89 (0·79–1·01) | 125 (13·3) | 0·78* (0·64–0·94) | 0·06 | 16·68 | < 0·001$ |
 | 1·00 (Ref) |  | 0·87***$ (0·81–0·92) |  | 0·92 (0·84–1·01) |  | 1·19* (1·03–1·38) |  | 1·19 (0·96–1·48) | 0·09 | 37·27 | < 0·001$ | |
 | PEs level1 N = 13,978 (29·7%) | PEs level2 N = 23,567 (50·1%) | PEs level3 N = 6402 (13·6%) | PEs level4 N = 2118 (4·5%) | PEs level5 N = 939 (2·0%) | Deviation From Linearity | |||||||
N (%) | OR | N (%) | OR (95%CI) | N (%) | OR (95%CI) | N (%) | OR (95%CI) | N (%) | OR (95%CI) | βa | χ2 | P-value | |
Family History | |||||||||||||
 Family History (psychosis) n = 338 (0·7%) | 67 (0·5) | 1·00 (Ref) | 159 (0·7) | 1·40* (1·05–1·86) | 69 (1·1) | 2·25***$ (1·60–3·15) | 27 (1·3) | 2·67***$ (1·70–4·18) | 16 (1·7) | 3·58***$ (2·06–6·19) | 0·05 | 1·10 | 0·29 |
 | 1·00 (Ref) |  | 1·26 (0·94–1·69) |  | 1·74** (1·20–2·54) |  | 1·82* (1·09–3·05) |  | 2·02* (1·03–3·94) | 0·10 | 0·03 | 0·86 | |
 Family History (non-psychosis) n = 440 (0·9%) | 79 (0·6) | 1·00 (Ref) | 214 (0·9) | 1·58***$ (1·22–2·05) | 87 (1·4) | 2·39***$ (1·76–3·25) | 50 (2·3) | 4·22***$ (2·95–6·03) | 10 (1·1) | 1·87 (0·97–3·62) | -0·01 | 0·01 | 0·91 |
 | 1·00 (Ref) |  | 1·42** (1·09–1·85) |  | 1·82***$ (1·29–2·55) |  | 2·79***$ (1·83–4·25) |  | 1·00 (0·48–2·11) | -0·05 | 1·06 | 0·30 | |
Adverse Childhood Experiences | |||||||||||||
 Loss of Parent (Divorce) n = 1102 (2·3%) | 191 (1·3) | 1·00 (Ref) | 546 (2·3) | 1·71***$ (1·45–2·02) | 219 (3·4) | 2·57***$ (2·11–3·12) | 85 (4·0) | 3·03***$ (2·34–3·94) | 61 (6·0) | 5·03***$ (3·74–6·77) | 0·03 | 0·93 | 0·34 |
 | 1·00 (Ref) |  | 1·61***$ (1·36–1·91) |  | 2·21***$ (1·78–2·74) |  | 2·42***$ (1·80–3·25) |  | 3·59***$ (2·50–5·16) | 0·00 | 0·01 | 0·92 | |
 Loss of Parent (Death) n = 632 (1·3%) | 145 (1·0) | 1·00 (Ref) | 304 (1·3) | 1·25* (1·02–1·53) | 114 (1·8) | 1·74***$ (1·36–2·23) | 48 (2·2) | 2·23***$ (1·60–3·10) | 21 (2·2) | 2·19***$ (1·38–3·49) | 0·06 | 2·41 | 0·12 |
 | 1·00 (Ref) |  | 1·16 (0·94–1·42) |  | 1·44** (1·09–1·90) |  | 1·68** (1·15–2·45) |  | 1·43 (0·83–2·46) | 0·03 | 0·55 | 0·46 | |
 Physical Abuse n = 14,785 (31·5%) | 3829 (27·4) | 1·00 (Ref) | 6773 (28·7) | 1·09***$ (1·04–1·14) | 2625 (41·0) | 1·88***$ (1·76–2·00) | 1019 (48·1) | 2·49***$ (2·27–2·74) | 539 (57·4) | 3·66***$ (3·20–4·19) | 0·17 | 253·88 | < 0·001$ |
 | 1·00 (Ref) |  | 1·01 (0·96–1·06) |  | 1·55***$ (1·44–1·66) |  | 1·87***$ (1·68–2·08) |  | 2·40***$ (2·06–2·80) | 0·14 | 171·46 | < 0·001$ | |
 Sexual Abuse n = 1360 (2·9%) | 311 (2·2) | 1·00 (Ref) | 666 (2·8) | 1·25**$ (1·09–1·43) | 208 (3·2) | 1·46***$ (1·22–1·75) | 102 (4·8) | 2·22***$ (1·77–2·79) | 73 (7·8) | 3·67***$ (2·82–4·78) | 0·13 | 25·67 | < 0·001$ |
 | 1·00 (Ref) |  | 1·12 (0·97–1·29) |  | 1·11 (0·91–1·35) |  | 1·46** (1·13–1·90) |  | 1·97***$ (1·42–2·74) | 0·08 | 9·50 | 0·002$ | |
 Neglect n = 16,056 (34·2%) | 3511 (25·1) | 1·00 (Ref) | 7707 (32·7) | 1·46***$ (1·39–1·53) | 3042 (45·7) | 2·72***$ (2·55–2·89) | 1198 (56·6) | 3·90***$ (3·55–4·29) | 598 (63·9) | 5·27***$ (4·59–6·05) | 0·12 | 128·09 | < 0·001$ |
 | 1·00 (Ref) |  | 1·32***$ (1·25–1·38) |  | 2·11***$ (1·97–2·27) |  | 2·69***$ (2·42–2·99) |  | 3·06***$ (2·62–3·57) | 0·09 | 64·77 | < 0·001$ | |
  > =2 maltreatment n = 10,567 (22.5%) | 2991 (21.4) | 1.00 (Ref) | 4531 (19.2) | 0.88***$ (0.84–0.93) | 1811 (28.3) | 1.46***$ (1.36–1.56) | 790 (37.3) | 2.20***$ (1.99–2.42) | 444 (47.3) | 3.33***$ (2.91–3.81) | 0.24 | 434 | < 0·001$ |
 | 1.00 (Ref) |  | 0.82***$ (0.77–0.86) |  | 1.20***$ (1.11–1.29) |  | 1.64***$ (1.47–1.83) |  | 2.17***$ (1.85–2.53) | 0.21 | 315.23 | < 0·001$ |