Table 2 Main effects of the FKBP5 polymorphisms on depressive symptoms
Variable | Model 1 | Model 2 | Model 3 | Model 4 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | P value | q value | Adjusted OR (95% CI) | P value | q value | Adjusted OR (95% CI) | P value | q value | Adjusted OR (95% CI) | P value | q value | ||
rs7757037* | |||||||||||||
Codominant model | AA vs. GG | 2.01 (0.94–4.34) | 0.074 | 0.111 | 2.17 (0.93–5.01) | 0.072 | 0.108 | 2.02 (0.86–4.78) | 0.109 | 0.163 | 1.98 (0.85–4.64) | 0.116 | 0.174 |
AG vs. GG | 2.35 (1.13–4.92) | 0.023 | 0.075** | 2.56 (1.13–5.78) | 0.024 | 0.062** | 2.34 (1.02–5.36) | 0.044 | 0.115 | 2.02 (0.89–4.63) | 0.095 | 0.174 | |
Dominant model | AA+AG vs. GG | 2.20 (1.10–4.39) | 0.025 | 0.075** | 2.38 (1.11–5.12) | 0.026 | 0.062** | 2.20 (1.01–4.78) | 0.048 | 0.115 | 2.00 (0.93–4.33) | 0.077 | 0.174 |
Recessive model | AA vs. AG + GG | 1.09 (0.63–1.89) | 0.748 | 0.748 | 1.10 (0.61–2.00) | 0.744 | 0.744 | 1.10 (0.60–2.02) | 0.762 | 0.762 | 1.21 (0.66–2.23) | 0.543 | 0.543 |
rs2817032* | |||||||||||||
Codominant model | TT vs. CC | 3.01 (1.18–7.70) | 0.022 | 0.075** | 3.63 (1.28–10.25) | 0.015 | 0.060** | 3.12 (1.09–8.89) | 0.034 | 0.115 | 2.90 (1.02–8.27) | 0.046 | 0.174 |
TC vs. CC | 2.77 (1.04–7.35) | 0.041 | 0.086** | 4.01 (1.35–11.89) | 0.012 | 0.060** | 3.16 (1.05–9.55) | 0.041 | 0.115 | 3.09 (1.03–9.24) | 0.044 | 0.174 | |
Dominant model | TT + TC vs. CC | 2.91 (1.17–7.27) | 0.022 | 0.075** | 3.76 (1.36–10.38) | 0.011 | 0.060** | 3.13 (1.12–8.74) | 0.029 | 0.115 | 2.97 (1.07–8.25) | 0.037 | 0.174 |
Recessive model | TT vs. TC + CC | 1.36 (0.81–2.28) | 0.243 | 0.265 | 1.24 (0.71–2.15) | 0.456 | 0.497 | 1.29 (0.73–2.29) | 0.385 | 0.420 | 1.22 (0.69–2.16) | 0.501 | 0.543 |
rs2817035* | |||||||||||||
Codominant model | GG vs. AA | 2.55 (1.03–6.32) | 0.043 | 0.086** | 2.93 (1.08–7.96) | 0.035 | 0.069** | 2.49 (0.90–6.86) | 0.079 | 0.158 | 2.37 (0.86–6.54) | 0.096 | 0.174 |
GA vs. AA | 2.07 (0.80–5.37) | 0.135 | 0.180 | 2.52 (0.88–7.20) | 0.085 | 0.113 | 2.05 (0.70–5.99) | 0.188 | 0.251 | 2.03 (0.70–5.90) | 0.194 | 0.259 | |
Dominant model | GG + GA vs. AA | 2.36 (0.98–5.72) | 0.056 | 0.096** | 2.78 (1.05–7.36) | 0.040 | 0.069** | 2.32 (0.86–6.25) | 0.095 | 0.163 | 2.24 (0.84–6.02) | 0.110 | 0.174 |
Recessive model | GG vs. GA + AA | 1.47 (0.87–2.47) | 0.151 | 0.181 | 1.45 (0.83–2.54) | 0.197 | 0.236 | 1.44 (0.81–2.57) | 0.219 | 0.263 | 1.38 (0.77–2.46) | 0.275 | 0.330 |
Parenting style of the father | |||||||||||||
Authoritarian | 1.00 (reference) | 1.00 (reference) | |||||||||||
Permissive | 0.26 (0.08–0.82) | 0.021 | NA | 0.19 (0.06–0.66) | 0.009 | NA | NA | NA | NA | NA | NA | NA | |
Authoritative | 0.24 (0.07–0.83) | 0.024 | NA | 0.22 (0.06–0.82) | 0.023 | NA | NA | NA | NA | NA | NA | NA | |
Neglectful | 4.62 (0.46–46.67) | 0.195 | NA | 3.15 (0.29–34.59) | 0.348 | NA | NA | NA | NA | NA | NA | NA | |
Parenting style of the mother | |||||||||||||
Authoritarian | 1.00 (reference) | 1.00 (reference) | |||||||||||
Permissive | 0.13 (0.03–0.60) | 0.009 | NA | 0.11 (0.02–0.53) | 0.006 | NA | NA | NA | NA | NA | NA | NA | |
Authoritative | 0.25 (0.05–1.27) | 0.095 | NA | 0.22 (0.04–1.21) | 0.081 | NA | NA | NA | NA | NA | NA | NA | |
Neglectful | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |