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Table 2 Main effects of the FKBP5 polymorphisms on depressive symptoms

From: Associations of FKBP5 polymorphisms and methylation and parenting style with depressive symptoms among Chinese adolescents

Variable Model 1 Model 2 Model 3 Model 4
OR (95% CI) P value q value Adjusted OR (95% CI) P value q value Adjusted OR (95% CI) P value q value Adjusted OR (95% CI) P value q value
rs7757037*
 Codominant model AA vs. GG 2.01 (0.94–4.34) 0.074 0.111 2.17 (0.93–5.01) 0.072 0.108 2.02 (0.86–4.78) 0.109 0.163 1.98 (0.85–4.64) 0.116 0.174
  AG vs. GG 2.35 (1.13–4.92) 0.023 0.075** 2.56 (1.13–5.78) 0.024 0.062** 2.34 (1.02–5.36) 0.044 0.115 2.02 (0.89–4.63) 0.095 0.174
 Dominant model AA+AG vs. GG 2.20 (1.10–4.39) 0.025 0.075** 2.38 (1.11–5.12) 0.026 0.062** 2.20 (1.01–4.78) 0.048 0.115 2.00 (0.93–4.33) 0.077 0.174
 Recessive model AA vs. AG + GG 1.09 (0.63–1.89) 0.748 0.748 1.10 (0.61–2.00) 0.744 0.744 1.10 (0.60–2.02) 0.762 0.762 1.21 (0.66–2.23) 0.543 0.543
rs2817032*
 Codominant model TT vs. CC 3.01 (1.18–7.70) 0.022 0.075** 3.63 (1.28–10.25) 0.015 0.060** 3.12 (1.09–8.89) 0.034 0.115 2.90 (1.02–8.27) 0.046 0.174
TC vs. CC 2.77 (1.04–7.35) 0.041 0.086** 4.01 (1.35–11.89) 0.012 0.060** 3.16 (1.05–9.55) 0.041 0.115 3.09 (1.03–9.24) 0.044 0.174
 Dominant model TT + TC vs. CC 2.91 (1.17–7.27) 0.022 0.075** 3.76 (1.36–10.38) 0.011 0.060** 3.13 (1.12–8.74) 0.029 0.115 2.97 (1.07–8.25) 0.037 0.174
 Recessive model TT vs. TC + CC 1.36 (0.81–2.28) 0.243 0.265 1.24 (0.71–2.15) 0.456 0.497 1.29 (0.73–2.29) 0.385 0.420 1.22 (0.69–2.16) 0.501 0.543
rs2817035*
 Codominant model GG vs. AA 2.55 (1.03–6.32) 0.043 0.086** 2.93 (1.08–7.96) 0.035 0.069** 2.49 (0.90–6.86) 0.079 0.158 2.37 (0.86–6.54) 0.096 0.174
GA vs. AA 2.07 (0.80–5.37) 0.135 0.180 2.52 (0.88–7.20) 0.085 0.113 2.05 (0.70–5.99) 0.188 0.251 2.03 (0.70–5.90) 0.194 0.259
 Dominant model GG + GA vs. AA 2.36 (0.98–5.72) 0.056 0.096** 2.78 (1.05–7.36) 0.040 0.069** 2.32 (0.86–6.25) 0.095 0.163 2.24 (0.84–6.02) 0.110 0.174
 Recessive model GG vs. GA + AA 1.47 (0.87–2.47) 0.151 0.181 1.45 (0.83–2.54) 0.197 0.236 1.44 (0.81–2.57) 0.219 0.263 1.38 (0.77–2.46) 0.275 0.330
Parenting style of the father
 Authoritarian   1.00 (reference)    1.00 (reference)         
 Permissive   0.26 (0.08–0.82) 0.021 NA 0.19 (0.06–0.66) 0.009 NA NA NA NA NA NA NA
 Authoritative   0.24 (0.07–0.83) 0.024 NA 0.22 (0.06–0.82) 0.023 NA NA NA NA NA NA NA
 Neglectful   4.62 (0.46–46.67) 0.195 NA 3.15 (0.29–34.59) 0.348 NA NA NA NA NA NA NA
Parenting style of the mother
 Authoritarian   1.00 (reference)    1.00 (reference)         
 Permissive   0.13 (0.03–0.60) 0.009 NA 0.11 (0.02–0.53) 0.006 NA NA NA NA NA NA NA
 Authoritative   0.25 (0.05–1.27) 0.095 NA 0.22 (0.04–1.21) 0.081 NA NA NA NA NA NA NA
 Neglectful   NA NA NA NA NA NA NA NA NA NA NA NA
  1. Abbreviations: OR, odds ratio; 95% CI, 95% confidence interval; NA, not applicable or not available
  2. *: Only the FKBP5 polymorphisms observed with a significant association of depressive symptoms in the unadjusted model were reported here
  3. Model 1: unadjusted models
  4. Model 2: adjusted for age, gender, living arrangement, and morning cortisol level
  5. Model 3: adjusted for age, gender, living arrangement, morning cortisol level, and parenting style of the father
  6. Model 4: adjusted for age, gender, living arrangement, morning cortisol level, and parenting style of the mother
  7. **: “q value” indicates the FDR-adjusted P value, and the results were considered as nominally significant when q < 0.10