Fig. 1

Sunburst of treatment patterns starting with first line (inner-most circle) to third line (outer circles). Each slice represents a treatment regimen, each color represents a distinct treatment class, and each layer represents a new regimen received and illustrates the sequence in which patients received different therapies; for example, the large brown piece in the top-middle indicates a first regimen of SSRI only, and the light blue slice on the next outer ring adjacent indicates a switch to an anxiolytic (2nd regimen). Slices that have multiple colors (e.g., brown + light blue) indicate a regimen of combination therapy with more than one medication class (e.g., SSRI + anxiolytic). Slices in light grey indicate no additional medication was taken. SSRI, selective serotonin reuptake inhibitor; SNRI, serotonin and norepinephrine reuptake inhibitor