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Table 2 Multivariate AFT model estimating associations of PGSs for ageing-related traits and risk for dementia diagnosis

From: Interplay between polygenic propensity for ageing-related traits and the consumption of fruits and vegetables on future dementia diagnosis

 

Total sample

Alzheimer’s diagnosis

non-AD cases

 

HR (95% CI)

HR (95% CI)

HR (95% CI)

AD-PGS

 PGS

1.24 (1.01–1.51) *

1.47 (1.00–2.18) *

1.16 (0.92–1.47)

  < 5 portions of fruit and vegetables

1.33 (1.03–1.73) *

1.48 (0.85–2.56)

1.30 (0.97–1.75)

 PGS × < 5 portions fruits & vegetables

1.05 (0.83–1.32)

0.91 (0.58–1.44)

1.10 (0.84–1.44)

SZ-PGS

 PGS

0.89 (0.74–1.07)

0.83 (0.58–1.18)

1.23 (0.97–1.55)

  < 5 portions of fruit and vegetables

1.37 (1.07–1.76) **

1.41 (0.85–2.36)

1.33 (0.99–1.78)

 PGS × < 5 portions fruits & vegetables

0.97 0.77–1.23)

1.66 (1.05–2.64) *

0.97 (0.73–1.30)

GC-PGS

 PGS

1.10 (0.90–1.34)

1.30 (0.88–1.92)

0.80 (0.65–0.98) *

  < 5 portions of fruit and vegetables

1.34 (1.04–1.72) *

1.46 (0.87–2.44)

1.37 (1.02–1.84) *

 PGS × < 5 portions fruits & vegetables

1.12 (0.88–1.44)

0.78 (0.48–1.29)

1.03 (0.78–1.35)

  1. Abbreviations: AFT Accelerated Failure Time; PGS polygenic score; AD-PGS polygenic score for Alzheimer’s disease; SZ-PGS polygenic score for schizophrenia; GC-PGS polygenic score for general cognition; HR hazard ratio; CI confidence interval; APOE-ε4 the ε4 allele of the apolipoprotein E gene
  2. × represents an interaction between the two factors; interactions are presented based on multiplicative interaction model
  3. * p-value ≤ .05; ** p-value ≤ .01; *** p-value ≤ .001