Peripheral and neural correlates of self-harm in children and adolescents: a scoping review

Sparrow-Downes, Victoria M.; Trincao-Batra, Sara; Cloutier, Paula; Helleman, Amanda R.; Salamatmanesh, Mina; Gardner, William; Baksh, Anton; Kapur, Rishi; Sheridan, Nicole; Suntharalingam, Sinthuja; Currie, Lisa; Carrie, Liam D.; Hamilton, Arthur; Pajer, Kathleen

doi:10.1186/s12888-022-03724-6

BMC Psychiatry

Table 1 Studies reviewed, type of self-harm, designs, specific correlates studied

From: Peripheral and neural correlates of self-harm in children and adolescents: a scoping review

Citation, Country	Type of Self-harm	Study Design	Specific Correlate
*Peripheral Correlates*
Robbins, Alessi 1985 US [54]	Suicidality	Case-control	Circadian rhythm, hypothalamic pituitary adreanal (HPA) axis, cortisol
Rosenthal et al. 1986 US [55]	Suicidality	Case-control	Circadian rhythm, HPA axis, cortisol
Dahl et al. 1991a US [56]	Suicidality	Case-control	Circadian rhythm, HPA axis, cortisol
Dahl et al. 1992a US [57]	Suicidality	Case-control	Circadian rhythm, HPA axis, cortisol
Ghaziuddin et al. 2014 US [58]	Suicidality	Case-control	Reactivity, HPA axis, cortisol
Young et al. 2010 Scotland [59]	Suicidality	Cross-sectional	Circadian rhythm, HPA axis, cortisol
Pfeffer et al. 1991 US [60]	Suicidality	Cohort	Circadian rhythm, HPA axis, cortisol
Giletta, et al. 2015 US [61]	Suicidality	Cohort	Reactivity, HPA axis, cortisol, predicting symptoms
Eisenlohr-Moul et al. 2018 US [62]	Suicidality	Cohort	Reactivity, HPA axis, cortisol, predicting symptoms
Reichl et al., 2016 Germany [63]	NSSI	Case-control	Circadian rhythm, HPA axis, cortisol
Klimes-Dougan et al. 2019 U S[64]	NSSI	Case-control	Reactivity, HPA axis, cortisol
Reichl, et al. 2019 Germany [65]	NSSI	Case-control	Circadian rhythm, Reactivity, HPA axis, cortisol
Beauchaine et al. 2015 US [66]	Any self-harm	Case-control	Circadian rhythm, HPA axis, cortisol
Plener et al. 2016 Germany [67]	Any self-harm	Cohort	Reactivity, HPA axis, cortisol
Yang et al., 2019 Hungary [68]	Suicidality	Case-control	Reactivity autonomic nervous system (ANS), cardiovascular (CV) system
Giletta et al., 2017 US [69]	Suicidality	Cohort	Reactivity, ANS, CV system, prediction symptoms
Koenig et al. 2017a Germany [70]	NSSI	Case-control	Resting, ANS, CV system
Crowell et al. 2005 US [51]	Any self-harm	Case-control	Resting & reactivity, ANS, CV system, skin conductance
Crowell et al. 2012 US [71]	Any self-harm	Case-control	Resting & reactivity, ANS, skin conductance
Wielgus et al. 2016 US [72]	Any self-harm	Cohort	Resting & reactivity, ANS, CV system, prediction symptoms
Aldrich et al. 2018 US [73]	Any self-harm	Cohort	Reactivity, ANS, skin conductance, prediction symptoms
Kaess et al. 2012 Germany [74]	NSSI	Case-control	Reactivity, HPA axis & ANS, cortisol, CV system
Koenig et al. 2017b Germany [75]	NSSI	Case-control	Reactivity, HPA axis & ANS, cortisol, CV system
Modai et al. 1989 Israel [76]	Suicidality	Case-control	Platelet serotonin function
Ambrosini et al. 1992 US [77]	Suicidality	Case-control	Platelet serotonin function
Pfeffer et al. 1998 US [78]	Suicidality	Case-control	Serotonin, precursor levels, platelet function
Tyano et al. 2006 Israel [79]	Suicidality	Case-control	Serotonin levels
Pine et al. 1995 US [80]	Suicidality	Cohort	Platelet serotonin function
Clark et al. 2003 US [81]	Suicidality	Cohort	Precursor levels, prediction symptoms
Crowell et al. 2005 US [51]	Any self-harm	Case-control	Serotonin levels
Crowell et al. 2008 US [82]	Any self-harm	Case-control	Serotonin levels
Dahl et al., 1990 US [83]	Suicidality	Case-control	Sleep characteristics
Dahl et al. 1991b US [84]	Suicidality	Case-control	Sleep characteristics
Emslie et al. 1994 US [85]	Suicidality	Case-control	Sleep characteristics
McCracken et al. 1997 US [86]	Suicidality	Case-control	Sleep characteristics
Boafo et al. 2019 Canada [87]	Suicidality	Case-control	Sleep characteristics
Singareddy et al. 2013 US [88]	Suicidality	Cohort	Sleep characteristics
Bilgiç et al. 2020 Turkey [89]	Suicidality	Case-control	Neurotrophin levels
Falcone et al. 2010 US [52]	Suicidality	Case-control	S100 calcium-binding protein B (S100B) levels
Falcone et al. 2015 US [90]	Suicidality	Case-control	S100B levels
Kavurma et al. 2017 Turkey [91]	Any self-harm	Case-control	Neurotrophin levels
Gabbay et al. 2009 US [92]	Suicidality	Case-control	Cytokine levels
Falcone et al. 2010 US (supplement data )[52]	Suicidality	Case-control	Cytokine levels
Amitai et al. 2020 Israel [93]	Suicidality	Non-controlled pre-post intervention	Cytokine levels, predicting side effects
Glueck et al. 1994 US [94]	Suicidality	Case-control	Lipid levels
Plana et al. 2010 Spain [95]	Suicidality	Case-control	Lipid levels
Ryan et al. 1988 US [96]	Suicidality	Case-control	Reactivity, growth hormone
Dahl et al.1992b US [97]	Suicidality	Case-control	Circadian rhythm, growth hormone
*Neural Correlates*
Pan et al. 2011 US [98]	Suicidality	Case-control	Brain activity, response inhibition
Pan et al. 2013a US [53]	Suicidality	Case-control	Brain activity, facial emotion processing
Pan et al. 2013b US [99]	Suicidality	Case-control	Brain activity, decision-making
Quevedo et al. 2016a US [100]	Suicidality	Case-control	Brain activity, emotion self-identity
Harms et al. 2019 US [101]	Suicidality	Case-control	Brain activity, social interaction
Oppenheimer et al. 2020 US [102]	Suicidality	Case-control	Brain activity, social interaction
Plener et al. 2012 Germany [103]	NSSI	Case-control	Brain activity, emotion processing
Groschwitz et al. 2016 Germany [104]	NSSI	Case-control	Brain activity, social interaction
Quevdo et al. 2016b US [105]	NSSI	Case-control	Brain activity, emotion self-identity
Brown et al. 2017 Germany [106]	NSSI	Case-control	Brain activity, social interaction
Perini et al. 2019 Sweden [107]	NSSI	Case-control	Brain activity, social interaction
Poon et al. 2019 US [108]	NSSI	Cross-sectional	Brain activity, reward processing
Sauder et al., 2016 US [109]	Any self-harm	Case-control	Brain activity, reward processing
Pan et al. 2013a US [53]	Suicidality	Case-control	Functional connectivity, facial emotion processing
Alarcon et al. 2019 US [110]	Suicidality	Case-control	Functional connectivity, emotion self-identity
Ordaz et al. 2018 US [111]	Suicidality	Cross-sectional	Functional connectivity, resting state
Schreiner al. 2018 US [112]	Suicidality	Cross-sectional	Functional connectivity, resting state
Schwartz et al. 2019 US [113]	Suicidality	Cohort	Functional connectivity, resting state, predicting symptom change
Santamarina-Perez et al. 2019 US [114]	NSSI	Cohort	Functional connectivity, resting state, predicting treatment effect
Tavakoli et al. 2018 Canada [115]	Suicidality	Case-control	Event-related potential, attention capture
Tsypes, et al. 2019 US [116]	Suicidality	Case-control	Event-related potential, reward-loss
Pegg et al. 2020 US [117]	Suicidality	Case-control	Event-related potential, reward-loss
Tsypes et al. 2018 US [118]	NSSI	Case-control	Event-related potential, reward-loss
Graae et al. 1996 US [119]	Suicidality	Case-control	Resting state, brain wave asymmetry
Lewis et al. 2019 US [120]	Suicidality	Non-controlled pre-post intervention	Reactive intracortical inhibition, post-treatment
Ho et al. 2018 US [121]	Suicidality	Cohort	Gray matter volume, predicting symptoms
Ando et al. 2018 Germany [122]	NSSI	Case-control	Gray matter volume
Beauchaine, et al. 2019 US [123]	Any self-harm	Case-control	Gray matter volume
Pan et al., 2015 US [124]	Suicidality	Case-control	Gray, white matter volumes
Goodman et al. 2011 US [125]	Any self-harm	Case-control	Gray and white matter volumes
Jovev et al. 2008 US [126]	Any self-harm	Cross-sectional	Pituitary gland volume

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