Table 3 Results of linear mixed model for repeated measures in predicting the changes in IL-1Ra levels from baseline to 6-month follow-up. The explaining variables in all models were gender and age as confounding factors, time from baseline to 6 months, regular smoking, alcohol use (AUD/non-AUD), depression severity at baseline in MADRS scores, and combined effects of time*AUD and time*MADRS. Estimates of factors gender, AUD, time, and time*AUD are for the following subgroups: female gender, non-AUD, baseline and the interaction of baseline*non-AUD. Interpretation of factor estimates accordingly: a negative estimate indicates lower biomarker levels in women or in non-AUD group at baseline. The combined effect of time*AUD and time*MADRS represents the effect of given variable (AUD / MADRS) on the change in the levels of IL-1Ra over time
From: The role of alcohol use and adiposity in serum levels of IL-1RA in depressed patients
Dependent variable: IL-1Ra change in 0–6 months | Estimate | 95% CI | SE | t | p |
|---|---|---|---|---|---|
Explaining variables: | |||||
Gender | 128.55 | −45.51 – 302.61 | 88.07 | 1.46 | 0.15 |
Age | −6.98 | −13.52 – –0.45 | 3.31 | −2.11 | 0.04 |
Time | 397.71 | 200.18–595.23 | 99.94 | 3.98 | < 0.001 |
Regular smoking | 35.84 | −129.76 – 201.44 | 83.74 | 0.43 | 0.67 |
AUD | 121.83 | −71.90 – 315.57 | 97.93 | 1.24 | 0.22 |
MADRS | 186.03 | 21.35–350.71 | 83.16 | 2.24 | 0.03 |
BMI | 42.40 | 30.16–54.63 | 6.19 | 6.86 | < 0.001 |
Time*AUD | − 183.42 | −387.80 – 0.95 | 103.38 | −1.77 | 0.08 |
Time*MADRS | − 279.49 | − 473.57 – –85.41 | 98.15 | −2.85 | 0.005 |