Abnormal pattern of vitamin D receptor-associated genes and lncRNAs in patients with bipolar disorder

Eghtedarian, Reyhane; Ghafouri-Fard, Soudeh; Bouraghi, Hamid; Hussen, Bashdar Mahmud; Arsang-Jang, Shahram; Taheri, Mohammad

doi:10.1186/s12888-022-03811-8

BMC Psychiatry

Table 3 The association between relative expressions of VDR-associated genes and BD based on the results of Bayesian Quantile regression model. When the interaction effects were significant, subgroup analysis by sex was performed to interpret the associations

From: Abnormal pattern of vitamin D receptor-associated genes and lncRNAs in patients with bipolar disorder

Comparisons		Posterior Beta of (2^(−ddct))^ʎ	SE	Adjusted P-value^a	95% Credible Intervals for Beta
SNHG6
Total	Patients vs. healthy subjects	1.299	0.2	< 0.0001	[0.89, 1.7]
	Females vs. Males	0.016	0.08	0.736	[-0.14, 0.18]
	Age (years)	-0.001	0.003	> 0.999	[-0.01, 0.005]
	Group ^a Sex	-0.539	0.13	0.04	[-0.78, -0.29]
Male	Patients vs. healthy subjects	0.772	0.1	< 0.0001	[0.58, 0.98]
Male	Age	-0.001	0.004	0.972	[-0.01, 0.01]
Female	Patients vs. healthy subjects	0.223	0.1	0.023	[0.04, 0.43]
Female	Age	-0.001	0.005	0.967	[-0.01, 0.01]
CYP27B1
Total	Patients vs. healthy subjects	0.415	0.07	< 0.0001	[0.28, 0.56]
	Females vs. Males	0.083	0.07	0.08	[-0.05, 0.21]
	Age (years)	0.003	0.003	0.19	[-0.002, 0.01]
	Group ^a Sex	-0.289	0.12	0.046	[-0.52, -0.06]
Male	Patients vs. healthy subjects	0.404	0.06	< 0.0001	[0.28, 0.53]
Male	Age	0.002	0.003	0.717	[-0.01, 0.01]
Female	Patients vs. healthy subjects	0.189	0.1	0.419	[-0.05, 0.36]
Female	Age	0.0001	0.006	0.178	[-0.01, 0.02]
MALAT1
Total	Patients vs. healthy subjects	0.694	0.1	< 0.0001	[0.5, 0.88]
	Females vs. Males	-0.019	0.08	0.624	[-0.18, 0.14]
	Age (years)	-0.003	0.003	0.294	[-0.01, 0.004]
	Group ^a Sex	-0.501	0.14	0.021	[-0.77, -0.23]
Male	Patients vs. healthy subjects	0.712	0.1	< 0.0001	[0.52, 0.9]
Male	Age	-0.002	0.004	0.439	[-0.01, 0.01]
Female	Patients vs. healthy subjects	0.186	0.13	0.096	[-0.07, 0.44]
Female	Age	-0.003	0.007	0.541	[-0.02, 0.01]
Linc00346
Total	Patients vs. healthy subjects	0.4	0.09	0.012	[0.21, 0.56]
	Females vs. Males	-0.041	0.07	0.078	[-0.17, 0.1]
	Age (years)	0.003	0.001	0.588	[-0.003, 0.01]
	Group ^a Sex	-0.251	0.12	0.012	[-0.48, -0.02]
Male	Patients vs. healthy subjects	0.41	0.08	0.038	[0.23, 0.56]
Male	Age	0.007	0.001	0.238	[-0.003, 0.02]
Female	Patients vs. healthy subjects	0.147	0.08	0.17	[-0.01, 0.3]
Female	Age	0.002	0.001	0.695	[-0.01, 0.01]
VDR
Total	Patients vs. healthy subjects	0.683	0.21	0.001	[0.29, 1.1]
	Females vs. Males	-0.088	0.12	0.292	[-0.33, 0.17]
	Age (years)	-0.006	0.01	0.596	[-0.02, 0.01]
	Group ^a Sex	-0.45	0.24	0.16	[-0.93, 0.004]
Linc00511
Total	Patients vs. healthy subjects	0.019	0.08	0.920	[-0.13, 0.18]
	Females vs. Males	0.015	0.1	0.175	[-0.18, 0.22]
	Age (years)	0.007	0.001	0.006	[0.001, 0.01]
	Group ^a Sex	0.088	0.13	0.658	[-0.17, 0.34]

^aEstimated from frequentist methods, ʎ: Power transformation value estimated from Box-cox or Yeo-Johnson methods

Back to article page

ISSN: 1471-244X

Contact us

Submission enquiries: bmcpsychiatry@biomedcentral.com
General enquiries: ORSupport@springernature.com