Fig. 4

Roles of AMPA receptors and BDNF-TrkB signaling in the antidepressant-like activity of (2R,6R)-HNK. A Representative Western blots of the protein levels in the five groups. Full-length blots are presented in Supplementary Figure 1, 2, 3. B–H The respective protein levels of GluA1, GluA2, BDNF, the p-TrkB/TrkB protein ratio, Narp, PSD95, and synaptophysin in the hippocampi of male mice. Data, normalized against the control, are shown as the mean ± SEM, with 6 mice/group. ***P < 0.001. N.S., not significant