Overall | US | France | Spain | Japan | China | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
LAI | Non-LAI | LAI | Non-LAI | LAI | Non-LAI | LAI | Non-LAI | LAI | Non-LAI | LAI | Non-LAI | |
Number of patients | 1132 | 3105 | 251 | 884 | 335 | 451 | 410 | 392 | 84 | 434 | 52 | 944 |
QoL | *** | ** | * | |||||||||
No impairment, n (%) | 85 (7.5) | 295 (9.5) | 9 (3.6) | 60 (6.8) | 24 (7.2) | 22 (4.9) | 39 (9.5) | 28 (7.1) | 8 (9.5) | 37 (8.5) | 5 (9.6) | 148 (15.7) |
Mild, n (%) | 336 (29.7) | 1318 (42.5) | 74 (29.5) | 322 (36.4) | 73 (21.8) | 144 (31.9) | 135 (32.9) | 161 (41.1) | 28 (33.3) | 202 (46.5) | 26 (50.0) | 489 (51.8) |
Moderate, n (%) | 526 (46.5) | 1150 (37.0) | 121 (48.2) | 364 (41.2) | 178 (53.1) | 207 (45.9) | 172 (42.0) | 164 (41.8) | 36 (42.9) | 166 (38.3) | 19 (36.5) | 249 (26.4) |
Severe, n (%) | 172 (15.2) | 298 (9.6) | 42 (16.7) | 112 (12.7) | 59 (17.6) | 73 (16.2) | 58 (14.2) | 32 (8.2) | 11 (13.1) | 26 (6.0) | 2 (3.9) | 55 (5.8) |
Very severe, n (%) | 13 (1.2) | 44 (1.4) | 5 (2.0) | 26 (2.9) | 1 (0.3) | 5 (1.1) | 6 (1.5) | 7 (1.8) | 1 (1.2) | 3 (0.7) | 0 (0.0) | 3 (0.3) |
Social function | *** | (n=3104) | ** | (n=943) | ||||||||
No impairment, n (%) | 76 (6.7) | 222 (7.2) | 13 (5.2) | 55 (6.2) | 22 (6.6) | 15 (3.3) | 34 (8.3) | 28 (7.1) | 3 (3.6) | 32 (7.4) | 4 (7.7) | 92 (9.8) |
Mild, n (%) | 310 (27.4) | 1120 (36.1) | 55 (21.9) | 254 (28.7) | 65 (19.4) | 115 (25.5) | 126 (30.7) | 132 (33.7) | 37 (44.1) | 171 (39.4) | 27 (51.9) | 448 (47.5) |
Moderate, n (%) | 460 (40.6) | 1220 (39.3) | 108 (43.0) | 383 (43.3) | 158 (47.2) | 192 (42.6) | 153 (37.3) | 150 (38.3) | 26 (31.0) | 189 (43.6) | 15 (28.9) | 306 (32.5) |
Severe, n (%) | 254 (22.4) | 484 (15.6) | 69 (27.5) | 170 (19.2) | 83 (24.8) | 119 (26.4) | 81 (19.8) | 69 (17.6) | 15 (17.9) | 37 (8.5) | 6 (11.5) | 89 (9.4) |
Very severe, n (%) | 32 (2.8) | 58 (1.9) | 6 (2.4) | 22 (2.5) | 7 (2.1) | 10 (2.2) | 16 (3.9) | 13 (3.3) | 3 (3.6) | 5 (1.2) | 0 (0.0) | 8 (0.9) |
Cognitive function | **** | ** | * | |||||||||
No impairment, n (%) | 154 (13.6) | 438 (14.1) | 26 (10.4) | 125 (14.1) | 30 (9.0) | 35 (7.8) | 72 (17.6) | 81 (20.7) | 17 (20.2) | 77 (17.7) | 9 (17.3) | 120 (12.7) |
Mild, n (%) | 414 (36.6) | 1489 (48) | 93 (37.1) | 407 (46.0) | 105 (31.3) | 159 (35.3) | 154 (37.6) | 159 (40.6) | 33 (39.3) | 197 (45.4) | 29 (55.8) | 567 (60.1) |
Moderate, n (%) | 421 (37.2) | 959 (30.9) | 102 (40.6) | 291 (32.9) | 143 (42.7) | 189 (41.9) | 134 (32.7) | 124 (31.6) | 29 (34.5) | 143 (33.0) | 13 (25.0) | 212 (22.5) |
Severe, n (%) | 133 (11.8) | 199 (6.4) | 28 (11.2) | 53 (6.0) | 55 (16.4) | 64 (14.2) | 44 (10.7) | 26 (6.6) | 5 (6.0) | 15 3.5) | 1 (1.9) | 41 (4.4) |
Very severe, n (%) | 10 (0.9) | 20 (0.6) | 2 (0.8) | 8 (0.9) | 2 (0.6) | 4 (0.9) | 6 (1.5) | 2 (0.5) | 0 (0.0) | 2 (0.5) | 0 (0.0) | 4 (0.4) |
Ability to meet own basic needs | ** | * | ||||||||||
No impairment, n (%) | 242 (21.4) | 732 (23.6) | 49 (19.5) | 201 (22.7) | 62 (18.5) | 109 (24.2) | 116 (28.3) | 125 (31.9) | 10 (11.9) | 58 (13.4) | 5 (9.6) | 239 (25.3) |
Mild, n (%) | 422 (37.3) | 1364 (43.9) | 84 (33.5) | 369 (41.7) | 126 (37.6) | 160 (35.5) | 141 (34.4) | 153 (39.0) | 38 (45.2) | 218 (50.2) | 33 (63.5) | 464 (49.2) |
Moderate, n (%) | 361 (31.9) | 793 (25.5) | 90 (35.9) | 242 (27.4) | 108 (32.2) | 130 (28.8) | 118 (28.8) | 92 (23.5) | 32 (38.1) | 132 (30.4) | 13 (25.0) | 197 (20.9) |
Severe, n (%) | 97 (8.6) | 192 (6.2) | 25 (10.0) | 59 (6.7) | 35 (10.5) | 49 (10.9) | 33 (8.1) | 19 (4.9) | 4 (4.8) | 23 (5.3) | 0 (0.0) | 42 (4.5) |
Very severe, n (%) | 10 (0.9) | 24 (0.8) | 3 (1.2) | 13 (1.5) | 4 (1.2) | 3 (0.7) | 2 (0.5) | 3 (0.8) | 0 (0.0) | 3 (0.7) | 1 (1.9) | 2 (0.2) |
Ability to work | ** | ** | ||||||||||
No impairment, n (%) | 71 (6.3) | 294 (9.5) | 7 (2.8) | 76 (8.6) | 17 (5.1) | 24 (5.3) | 41 (10.0) | 44 (11.2) | 3 (3.6) | 30 (6.9) | 3 (5.8) | 120 (12.7) |
Mild, n (%) | 256 (22.6) | 1007 (32.4) | 45 (17.9) | 240 (27.2) | 61 (18.2) | 88 (19.5) | 96 (23.4) | 96 (24.5) | 29 (34.5) | 196 (45.2) | 25 (48.1) | 387 (41.0) |
Moderate, n (%) | 326 (28.8) | 929 (29.9) | 84 (33.5) | 239 (27.0) | 86 (25.7) | 107 (23.7) | 101 (24.6) | 107 (27.3) | 34 (40.5) | 172 (39.6) | 21 (40.4) | 304 (32.2) |
Severe, n (%) | 330 (29.2) | 625 (20.1) | 81 (32.3) | 217 (24.6) | 126 (37.6) | 158 (35.0) | 106 (25.9) | 98 (25.0) | 14 (16.7) | 27 (6.2) | 3 (5.8) | 125 (13.2) |
Very severe, n (%) | 149 (13.2) | 250 (8.1) | 34 (13.6) | 112 (12.7) | 45 (13.4) | 74 (16.4) | 66 (16.1) | 47 (12.0) | 4 (4.8) | 9 (2.1) | 0 (0.0) | 8 (0.9) |
Overall general health | (n=3104) | *** | (n=943) | |||||||||
No impairment, n (%) | 175 (15.5) | 512 (16.5) | 18 (7.2) | 140 (15.8) | 56 (16.7) | 97 (21.5) | 91 (22.20) | 91 (23.2) | 7 (8.3) | 45 (10.4) | 3 (5.8) | 139 (14.74) |
Mild, n (%) | 456 (40.3) | 1527 (49.2) | 109 (43.4) | 394 (44.6) | 122 (36.4) | 162 (35.9) | 153 (37.3) | 169 (43.1) | 40 (47.6) | 245 (56.5) | 32 (61.5) | 557 (59.1) |
Moderate, n (%) | 415 (36.7) | 909 (29.3) | 98 (39.0) | 296 (33.5) | 138 (41.2) | 155 (34.4) | 132 (32.2) | 113 (28.8) | 31 (36.9) | 128 (29.5) | 16 (30.8) | 217 (23.0) |
Severe, n (%) | 75 (6.6) | 144 (4.6) | 19 (7.6) | 44 (5.0) | 18 (5.4) | 35 (7.8) | 31 (7.6) | 19 (4.9) | 6 (7.1) | 16 (3.7) | 1 (1.92) | 30 (3.2) |
Very severe, n (%) | 11 (1.0) | 12 (0.4) | 7 (2.8) | 10 (1.1) | 1 (0.3) | 2 (0.4) | 3 (0.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
Overall level of function | ** | |||||||||||
No impairment, n (%) | 71 (6.3) | 260 (8.4) | 9 (3.6) | 42 (4.8) | 24 (7.2) | 19 (4.2) | 31 (7.6) | 32 (8.2) | 6 (7.1) | 33 (7.6) | 1 (1.9) | 134 (14.2) |
Mild, n (%) | 370 (32.7) | 1342 (43.2) | 71 (28.3) | 346 (39.1) | 85 (25.4) | 138 (30.6) | 145 (35.4) | 157 (40.1) | 38 (45.2) | 198 (45.6) | 31 (59.6) | 503 (53.3) |
Moderate, n (%) | 469 (41.4) | 1145 (36.9) | 117 (46.6) | 365 (41.3) | 140 (41.8) | 190 (42.1) | 160 (39.0) | 153 (39.0) | 32 (38.1) | 173 (39.9) | 20 (38.5) | 264 (28.0) |
Severe, n (%) | 203 (17.9) | 306 (9.9) | 53 (21.1) | 107 (12.1) | 84 (25.1) | 94 (20.8) | 60 (14.6) | 39 (10.0) | 6 (7.1) | 26 (6.0) | 0 0.0) | 40 (4.2) |
Very severe, n (%) | 19 (1.7) | 52 (1.7) | 1 (0.4) | 24 (2.7) | 2 (0.6) | 10 (2.2) | 14 (3.4) | 11 (2.8) | 2 (2.4) | 4 (0.9) | 0 (0.0) | 3 (0.3) |