Previous exposure to antipsychotic drug treatment is an effective predictor of metabolic disturbances experienced with current antipsychotic drug treatments

Table 1 Changes in weight and metabolic parameters after olanzapine treatment

Variable and Week	Mean	SD	P
Weight (kg)
Weight 0	60.06	10.96
Weight 4	62.28	10.86	<0.001
Weight 6	63.16	10.91	<0.001
Body mass index (kg/m²)
Weight 0	22.53	4.57
Weight 4	23.42	4.71	<0.001
Weight 6	23.75	4.71	<0.001
Triglycerides (mmol l⁻¹)
Weight 0	1.22	0.71
Weight 4	1.85	1.20	<0.001
Weight 6	1.84	1.12	<0.001
Cholesterol (mmol l⁻¹)
Weight 0	4.21	0.89
Weight 4	4.56	0.94	<0.001
Weight 6	4.56	0.91	<0.001
HDL-C (mmol l⁻¹)
Weight 0	1.34	0.38
Weight 4	1.31	0.35	0.171
Weight 6	1.32	0.38	0.621
LDL-C (mmol l⁻¹)
Weight 0	2.41	0.76
Weight 4	2.65	0.85	<0.001
Weight 6	2.62	0.84	<0.001
Fasting glucose (mmol l⁻¹)
Weight 0	4.87	0.67
Weight 4	4.86	0.87	0.894
Weight 6	4.93	0.80	0.113

HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol

ISSN: 1471-244X