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Table 1 Demographic and clinical characteristics

From: Altered voxel-level whole-brain functional connectivity in multiple system atrophy patients with depression symptoms

Characteristics (Mean ± SD)

Control (n = 34)

MSA-D (n = 32)

MSA-ND (n = 30)

F/χ2

P-value

Age (years)

63.97 ± 5.08

63.03 ± 5.94

64.70 ± 7.74

0.55

0.58

Gender (male: female)

20:24

16:16

16:14

0.26

0.77

Education

11.44 ± 3.11

11.00 ± 4.31

11.27 ± 3.61

0.12

0.89

Disease duration

N

3.17 ± 1.63

3.57 ± 1.83

0.48

0.49

UMSARS score

N

33.22 ± 17.47

28.05 ± 18.63

0.05

0.83

Hoehn and Yahr

N

2.53 ± 1.09

2.37 ± 1.16

0.14

0.71

LEDD (mg/day)

N

335.94 ± 292.10

330.00 ± 354.31

0.94

0.17

Clinical phenotype (P/C)

N

15:17

13:17

0.28

0.60

MMSE score

28.78 ± 1.35

28.00 ± 1.78

28.40 ± 1.04

2.37

0.58

HAMD-24 score

1.5 ± 1.81

20.00 ± 6.25

4.80 ± 2.44

196.59

0.00*

HAMA-14 score

1.15 ± 1.10

3.44 ± 1.52

3.23 ± 1.71

24.98

0.00*

Dopamine agonists

N

20.16 ± 35.01

33.33 ± 76.38

2.61

0.11

  1. SD Standard deviation, MSA Multiple system atrophy, MSA-D Multiple system atrophy with depression symptoms, MSA-ND Multiple system atrophy without depression symptoms, HC Healthy controls, UMSARS Unified Multiple System Atrophy Rating Scale, LEDD Levodopa Equivalent dose, P/C Parkinson’s type/Cerebellar type, MMSE Mini-Mental State Examination, HAMD-24 24 items Hamilton Depression Scale. p < 0.05 was considered statistically significant. *:p<0.001.HAMA-14: 14 items Hamilton Anxiety Scale