Table 3 Correlation between daily clozapine dose and serum clozapine level
From: Factors predicting serum clozapine levels in Middle Eastern patients: an observational study
Patients (N) | Serum level (ng/mL) Mdn ± IQR (Range) | Daily dose (mg) M ± SD (Range) | Correlation (rs) (95% CI) | Significance (p) | C/D ratio (Serum level / Daily dose) |
|---|---|---|---|---|---|
All (94) | 705 ± 442.25–979.5 (105–3388) | 400 ± 149.69 (75–800) | 0.321 (0.127, 0.492) | 0.002 | 1.76 |
Monotherapy (33) | 599 ± 262–827.5 (127–2326) | 375.76 ± 150.97 (100–600) | 0.396 (0.061, 0.651) | 0.023 | 1.59 |
Monotherapy and Non-Smoker (22) | 656.5 ± 454.75–837.25 (182–2326) | 377.29 ± 160.71 (100–600) | 0.480 (0.124, 0.754) | 0.024 | 1.74 |
Polytherapy (61) | 799 ± 505.5–1054.5 (105–3388) | 413.11 ± 148.58 (75–800) | 0.245 (−0.007, 0.468) | 0.057 | 1.93 |