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Table 2 Outcomes of BAMBI, BASCET and BATSCH trials

From: Single-case experimental designs for bumetanide across neurodevelopmental disorders: BUDDI protocol

Domain

Outcome measure

BAMBI

BASCET

BATSCH

Behavioral outcomes

Social communication and interaction

SRS-2 (subscales social awareness, social cognition, social communication, social motivation)

Xa

X

X

Restricted, repetitive patterns of behavior

SRS-2 (subscale mannerisms)

Xa

X

X

RBS-r

X

X

X

Aberrant behavior

ABC

X

Xa

Xa

Sensitivity to sensory stimuli and Sensory stimulation tolerance

SP-NL

X

X

X

SP-SC

 

X

X

HSP

X

X

 

Quality of life and social improvement

Quality of life

QoL

X

X

X

EQ-5D-5L

X

X

X

EQ-5D-Y

X

X

X

pedsQL

 

X

X

Executive functions

TRF

X

 

X

BRIEF

X

 

X

Economic evaluation

iPCQ

X

 

X

TIC-P

X

 

X

Disease specific outcomes

TSC

TAND checklist

  

X

Epilepsy

Epilepsy variables

 

X

 

Cognitive measurements

Working memory

Digit span of the WISC-III, spatial span of the Wechsler Nonverbal scale of ability

X

 

X

Memory

Rey auditory verbal learning test, rey visual design learning test

X

 

X

Semantic memory

Recalling sentences subtest of the clinical evaluation of language fundamentals

X

 

X

Baseline response speed

ANT

X

 

X

Prepotent response inhibition

Go-nogo task and condition two of the auditory and visual shifting set tasks of the ANT

X

 

X

Attentional flexibility

Condition three of the auditory and visual shifting set tasks of the ANT

X

 

X

Neurophysiological outcomes

rsEEG

Alpha relative and absolute power, central frequency, detrended fluctuation analysis and excitation/inhibition ratio

X

 

X

ERP

PPI paradigm, P50 paradigm, mismatch negativity paradigm, selective attention paradigm

X

 

X

  1. Primary outcome measures are marked witha ABC Aberrant behavior scale, ANT Amsterdam neuropsychological task battery, BRIEF: behavior rating inventory of executive function, EQ-5D-5L 5-level EuroQoL 5-dimensional questionnaire, EQ-5D-Y 5-level EuroQoL 5-dimensional questionnaire, youth version, ERP: event-related potential, HSP highly sensitive child or parent scale, iPCQ productivity cost questionnaire, pedsQL pediatric quality of life inventory, QoL quality of life, RBS-r repetitive behavior scale revised, rsEEG resting state electro-encephalogram, SP-NL sensory profile, Dutch version, SP-SC sensory profile, school companion, SRS-2 social responsiveness scale, second edition, TAND tuberous sclerosis associated neuropsychiatric disorders, TiC-P Trimbos/iMTA questionnaire for Costs associated with Psychiatric Illness, TRF teacher report form, TSC tuberous sclerosis complex