Fig. 1

a Study Design: In the three study arms participants perform a cognitive assessment four times with an interval of 3 months in-between. Neuroimaging is performed at baseline and after 3 months in all study arms. After 6 months neuroimaging is performed in the cognitive training and the waitlist control group and after 9 months in the waitlist control group only. Blood samples are collected once, in the first group appointment. b Assessment: Each assessment has a duration of approximately 3 hours if neuroimaging is included. Abbreviations Figure a: CCT = Computerized cognitive training, CG = Control group, A = Assessment, o = Neuroimaging. Abbreviations Figure b: MoCA = Montreal Cognitive Assessment, AVLT = Auditory verbal learning test, GNT = Graded naming test, fMRI = Functional magnetic resonance Imaging, ASL = Arterial spin labelling