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Table 2 PANS symptom profiles at Baseline

From: Paediatric Acute-onset Neuropsychiatric Syndrome (PANS) and intravenous immunoglobulin (IVIG): comprehensive open-label trial in ten children

PANS symptoms

Presence of symptoms at baseline in percent

(n = 10)

Mean value PANS

score

Major PANS criteria

Obsessive- compulsive symptoms

10 (100%)

3.8

Eating restriction

8 (80%)

2.4

Minor PANS criteria

1. Anxiety symptoms

  Separation anxiety

9 (90%)

2.9

  General anxiety

10 (100%)

3.6

  Irrational fears/phobias

8 (80%)

3.0

  Panic episodes

9 (90%)

2.5

2. Emotional lability, depression

  Emotional lability, mood swings

10 (100%)

3.8

  Depression with/without suicidal/self-injurious thoughts

8 (80%)

2.2

3. Increased irritability or aggressive behavior

10 (100%)

3.9

4. Behavioral regression

  Behavioral regression (behavior atypical for actual age)

8 (80%)

2.4

  Change in personality

10 (100%)

3.3

5. School performance, concentration/learning

  Difficulties in attention, concentration or learning

9 (90%)

3.0

  Loss of academic skills (math, reading, writing)

8 (80%)

3.1

  Confusion

0%

0

6A. Sensory symptoms

10 (100%)

3.6

6B. Hallucinations

2 (20%)

0.7

6C. Motor symptoms

  Dysgraphia

6 (60%)

1.9

  Motoric hyperactivity

9 (90%)

3.0

  Piano playing movements

2 (20%)

0.2

  Simple motor/vocal tics

7 (70%)

2.0

  Complex motor/vocal tics

4 (40%)

0.9

7A. Urinary symptoms

4 (40%)

1.0

7B. Sleep disturbance, fatigue

  Sleep problems

7 (70%)

1.8

  Extreme tiredness or fatigue

8 (80%)

2.7

7C. Dilated pupils

7 (70%)

1.7

Body pain

7 (70%)

 
  1. The PANS symptom severity scores are rated between 0 (no symptoms) and 5 (extreme symptoms)