Fig. 2
Treatment changes and psychotherapy and combination therapy trends. A Pharmacological treatment changes at the end of the first regimen observed and time to discontinuation1−4. B Combination and psychotherapy use trend5. Notes: [1] Treatment discontinuation was defined as having no ADHD-related agents (of any type) for at least 180 consecutive days following the last day of supply of all ADHD-related agents included in the previous treatment regimen. [2] Treatment switch was defined as the initiation of a new ADHD-related agent (not part of the previous treatment regimen) with no prescription fills of the last ADHD-related agent(s) included in the previous treatment regimen within the 30 days following the newly initiated ADHD-related agent. [3] Treatment add-on was defined as the initiation of a new ADHD-related agent (not part of the previous treatment regimen) with at least one additional prescription fill of the last ADHD-related agent(s) included in the previous treatment regimen, within the 30 days following the newly initiated ADHD-related agent. [4] Treatment drop was defined as the discontinuation of an ADHD-related agent from a treatment regimen while the other agent(s) from treatment regimen are not discontinued for at least enough time to define a new regimen. [5] Psychotherapy and combination therapy of ≥ 2 therapeutic agents were measured between the start and the end of the treatment regimen. Psychotherapy may be underreported in claims