Table 2 CATIE population baseline scale scores by PANSS Item G12 insight rating
Assessments, mean (SD) | PANSS Item G12 Rating | Â | |||||
|---|---|---|---|---|---|---|---|
1 Absent n = 309 | 2 Minimal n = 258 | 3 Mild n = 387 | 4 Moderate n = 339 | 5 Moderate-Severe n = 80 | 6/7 Severe/Extreme n = 58 | P value* | |
Patient-reported outcomes | |||||||
 Mental/emotional health item | 58.5 (26.3) | 58.0 (26.1) | 59.1 (26.1) | 59.0 (27.7) | 72.7 (26.7) | 74.1 (28.5) | < 0.0001 |
 SF-12 PCS | 47.7 (10.8) | 47.7 (10.1) | 48.1 (10.6) | 48.3 (9.9) | 50.5 (7.8) | 50.3 (8.1) | < 0.0001 |
 SF-12 MCS | 39.7 (12.0) | 40.2 (11.0) | 40.0 (11.5) | 41.4 (11.2) | 44.4 (11.9) | 49.1 (11.7) | < 0.0001 |
Schizophrenia severity | |||||||
 CGI-S | 3.7 (1.0) | 3.8 (0.9) | 3.9 (0.9) | 4.2 (0.9) | 4.5 (1.0) | 4.6 (1.0) | < 0.0001 |
 PGI-S | 3.5 (1.5) | 3.6 (1.6) | 3.6 (1.5) | 3.6 (1.6) | 3.0 (1.7) | 2.6 (1.7) | < 0.0001 |
PANSS components** | |||||||
 Negative | 17.5 (6.4) | 20.1 (5.8) | 21.6 (6.1) | 23.3 (6.9) | 24.1 (7.2) | 27.1 (8.0) | < 0.0001 |
 Positive | 14.2 (5.3) | 15.5 (4.8) | 17.0 (4.8) | 18.7 (5.7) | 19.1 (6.0) | 20.0 (6.2) | < 0.0001 |
 Cognitive | 13.5 (4.2) | 16.5 (4.2) | 18.2 (4.0) | 20.6 (4.4) | 23.2 (4.7) | 24.8 (5.6) | < 0.0001 |
 Emotional discomfort | 10.6 (4.2) | 11.2 (3.6) | 11.4 (3.6) | 11.2 (3.9) | 10.3 (3.6) | 9.1 (3.2) | < 0.0001 |
 Hostility | 6.0 (2.5) | 6.7 (2.5) | 7.5 (2.8) | 7.5 (3.1) | 8.1 (3.2) | 7.8 (3.8) | < 0.0001 |
Neurocognitive Composite Score (MCCB)*** | 51.3 (9.8) | 51.3 (9.7) | 49.8 (9.3) | 48.7 (11.1) | 46.8 (10.0) | 49.2 (9.7) | 0.1648 |
Calgary total score | 5.0 (4.8) | 4.9 (4.3) | 4.8 (4.4) | 4.3 (4.3) | 2.9 (3.7) | 2.1 (2.4) | < 0.0001 |