Table 3 Adverse drug reactions induced by pDDIs

Constipation

31

26.05

Abnormal liver function

14

11.76

Abnormal routine blood examination

8

6.72

Abnormal Electrocardiogram

7

5.88

Hypersomnia

6

5.04

Sweat

6

5.04

Dizziness and fainting

5

4.20

Tachycardia

3

2.52

Dry mouth

2

1.68

Headache

2

1.68

Hypertension

2

1.68

Loss of appetite or anorexia

2

1.68

Akathisia

1

0.84

Decreased activity

1

0.84

Increased salivation

1

0.84

Insomnia

1

0.84

Muscle rigidity

1

0.84

Nausea and vomiting

1

0.84

Tremor

1

0.84

 Fatigue

8

6.72

 Flustered

4

3.36

 Lower extremity edema

3

2.52

 Unsteady walking

3

2.52

 Gastric distress

2

1.68

 Physical discomfort

2

1.68

 Tongue or hand numbness

2

1.68