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Table 2 Baseline characteristics and comparison of the changes within and between groups following the interventiona

From: Effects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial

Variable

Group

Intervention (n = 28)

Control (n = 28)

Between-group P** value

Before

After

P* value

Before

After

P* value

Before

After

25(OH)D (nmol L−1)

87.1 (28.55)

127.92 (24.93)

 < 0.001

73.64 (31.94)

78.77 (27.05)

0.26

0.10

 < 0.001

Serum iPTH (pg mL−1)

13.26 (14.39)

13.43 (9.30)

0.07

11.08 (8.33)

16.18 (7.92)

 < 0.001

0.64

0.07

hs-CRP (mg L−1)

4.40 (3.03)

4.67 (3.39)

0.7

5.29 (4.57)

4.07 (3.71)

0.13

0.97

0.18

IL-1β (pg mL−1)

39.83 (33.15)

41.04 (36.45)

0.67

30.85 (34.15)

33.76 (28.80)

0.41

0.15

0.76

IL-6 pg mL−1)

2.08 (0.63)

1.98 (0.44)

0.85

3.23 (5.27)

3.39 (6.66)

0.13

0.26

0.31

BDI-II score

23.86 (5.49)

12.11 (6.12)

 < 0.001

21.79 (5.74)

18.18 (12.82)

0.053

0.23

0.003

  1. 25(OH)D 25-hydroxyvitamin D, iPTH intact parathormone, hs-CRP high-sensitivity C-reactive protein, IL-1β interleukin-1β, IL-6 interleukin-6, BDI-II Beck Depression Inventory-II
  2. aAll values are means (± SDs)
  3. *Denotes the significance of within-group changes, paired sample t-test (for normal distribution), Wilcoxon test (for non-normal distribution)
  4. **Denotes the significance of between-group changes, independent sample t-test (for normal distribution), Mann–Whitney test (for non-normal distribution)